ReviewPharmaceutical research1996
Pharmaceutical approach to somatic gene therapy.
Review in Pharmaceutical research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Mechanisms and Strategies for Enhancing DNA Nuclear Entry in Gene Delivery.Cellular and molecular bioengineering · 2026Article
- Advancing cancer gene therapy: the emerging role of nanoparticle delivery systems.Journal of nanobiotechnology · 2025Review
- Effects of inhalable gene transfection as a novel gene therapy for non-small cell lung cancer and malignant pleural mesothelioma.Scientific reports · 2022Article
- Article
- Article
- Using inositol as a biocompatible ligand for efficient transgene expression.International journal of nanomedicine · 2015Article
- Surface polyethylene glycol enhances substrate-mediated gene delivery by nonspecifically immobilized complexes.Acta biomaterialia · 2008Article
- Non-viral vector delivery from PEG-hyaluronic acid hydrogels.Journal of controlled release : official journal of the Controlled Release Society · 2007Article
- Gene therapy of the other genome: the challenges of treating mitochondrial DNA defects.Pharmaceutical research · 2007Review
- Multiple and time-scheduled in situ DNA delivery mediated by beta-cyclodextrin embedded in a polyelectrolyte multilayer.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Substrate-mediated delivery from self-assembled monolayers: effect of surface ionization, hydrophilicity, and patterning.Acta biomaterialia · 2005Article
- Characterisation of systemic dissemination of nonreplicating adenoviral vectors from tumours in local gene delivery.British journal of cancer · 2005Article
- Novel PDGFbetaR antisense encapsulated in polymeric nanospheres for the treatment of restenosis.Gene therapy · 2002Article
- In vitro transfection of plasmid DNA by amine derivatives of gelatin accompanied with ultrasound irradiation.Pharmaceutical research · 2002Article
- Polyion complex micelles as vectors in gene therapy--pharmacokinetics and in vivo gene transfer.Gene therapy · 2002Article
- Dendritic cell delivery of plasmid DNA. Applications for controlled genetic immunization.Molecular biotechnology · 2001Review
- Synthesis of a novel series of cationic lipids that can act as efficient gene delivery vehicles through systematic heterocyclic substitution of cholesterol derivatives.Gene therapy · 2001Article
- Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles.Gene therapy · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pharmaceutical approach to somatic gene therapy is based on consideration of a gene as a chemical entity with specific physical, chemical and colloidal properties. The genes that are required for gene therapy are large molecules (> 1 x 10(6) Daltons, > 100 nm diameter) with a net negative charge that prevents diffusion through biological barriers such as an intact endothelium, the plasma membrane or the nuclear membrane. New methods for gene therapy are based on increasing knowledge of the pathways by which DNA may be internalized into cells and traffic to the nucleus, pharmaceutical experience with particulate drug delivery systems, and the ability to control gene expression with recombined genetic elements. This article reviews two themes in the development of gene therapies: first, the current approaches involving the administration of cells, viruses and plasmid DNA; second, the emerging pharmaceutical approach to gene therapy based on the pharmaceutical characteristics of DNA itself and methods for advanced drug delivery.
Indexed as
Identifiers
8956323What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.