ArticleJournal of bacteriology1996
Phosphorylation-independent bacterial chemoresponses correlate with changes in the cytoplasmic level of fumarate.
Article in Journal of bacteriology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Biphasic chemotaxis ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Energy complexes are apparently associated with the switch-motor complex of bacterial flagella.Journal of molecular biology · 2012Article
- The bacterial flagellar switch complex is getting more complex.The EMBO journal · 2008Article
- Diversity in chemotaxis mechanisms among the bacteria and archaea.Microbiology and molecular biology reviews : MMBR · 2004Review
- Signal processing and flagellar motor switching during phototaxis of Halobacterium salinarum.Genome research · 2003Article
- Light-induced behavioral responses (;phototaxis') in prokaryotes.Photosynthesis research · 2003Article
- Fumarate-mediated inhibition of erythrose reductase, a key enzyme for erythritol production by Torula corallina.Applied and environmental microbiology · 2002Article
- Elucidation of a PTS-carbohydrate chemotactic signal pathway in Escherichia coli using a time-resolved behavioral assay.Molecular biology of the cell · 1999Article
- Response regulator output in bacterial chemotaxis.The EMBO journal · 1998Article
- Regulation of switching frequency and bias of the bacterial flagellar motor by CheY and fumarate.Journal of bacteriology · 1998Article
- Acetylation at Lys-92 enhances signaling by the chemotaxis response regulator protein CheY.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Bacterial locomotion and signal transduction.Journal of bacteriology · 1998Review
- A tricarboxylic acid cycle intermediate regulating transcription of a chloroaromatic biodegradative pathway: fumarate-mediated repression of the clcABD operon.Journal of bacteriology · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial chemotaxis is based on modulation of the probability to switch the direction of flagellar rotation. Responses to many stimuli are transduced by a two-component system via reversible phosphorylation of CheY, a small cytoplasmic protein that directly interacts with the switch complex at the flagellar motor. We found that the chemorepellents indole and benzoate induce motor switching in Escherichia coli cells with a disabled phosphorylation cascade. This phosphorylation-independent chemoresponse is explained by reversible inhibition of fumarase by indole or benzoate which leads to an increased level of cellular fumarate, a compound involved in motor switching for bacteria and archaea. Genetic deletion of fumarase increased the intracellular concentration of fumarate and enhanced the switching frequency of the flagellar motors irrespective of the presence or absence of the phosphorylation cascade. These correlations provide evidence for fumarate-dependent metabolic signal transduction in bacterial chemosensing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.