ArticleThe Plant cell1996
A polyketide synthase is required for fungal virulence and production of the polyketide T-toxin.
Article in The Plant cell, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 204 citations in OpenAlex.
- Article
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- Comparative genomic and phenotypic analyses of pathogenic fungi Neoscytalidium dimidiatum and Bipolaris papendorfii isolated from human skin scraping.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Population Genomic Evidence for a Repeated Introduction and Rapid Expansion of the Fungal Maize Pathogen Setosphaeria turcica in Europe.Genome biology and evolution · 2023Article
- High Diversity of Type I Polyketide Genes inJournal of fungi (Basel, Switzerland) · 2022Article
- In silico analyses of maleidride biosynthetic gene clusters.Fungal biology and biotechnology · 2022Article
- Recent Molecular Tools for the Genetic Manipulation of Highly Industrially Important Mucoromycota Fungi.Journal of fungi (Basel, Switzerland) · 2021Review
- Quantitative Proteomics Analysis Reveals the Function of the Putative Ester Cyclase UvEC1 in the Pathogenicity of the Rice False Smut FungusInternational journal of molecular sciences · 2021Article
- Recent Advances in Genome Editing Tools in Medical Mycology Research.Journal of fungi (Basel, Switzerland) · 2021Review
- Reference genome assembly for Australian Ascochyta lentis isolate Al4.G3 (Bethesda, Md.) · 2021Article
- Fungal Extracellular Vesicles in Pathophysiology.Sub-cellular biochemistry · 2021Article
- Uncovering biosynthetic relationships between antifungal nonadrides and octadrides.Chemical science · 2020Article
- Transcript profiling reveals potential regulators for oxidative stress response of a necrotrophic chickpea pathogen3 Biotech · 2020Article
- Acquisition and Loss of Secondary Metabolites Shaped the Evolutionary Path of Three Emerging Phytopathogens of Wheat.Genome biology and evolution · 2019Article
- The architectures of iterative type I PKS and FAS.Natural product reports · 2018Review
- Environmental pH modulates transcriptomic responses in the fungus Fusarium sp. associated with KSHB Euwallacea sp. near fornicatus.BMC genomics · 2018Article
- Polyketide synthases of Diaporthe helianthi and involvement of DhPKS1 in virulence on sunflower.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Race T of the fungal pathogen Cochliobolus heterostrophus is highly virulent toward Texas male sterile (T) maize and differs from its relative, race O, at a locus (Tox1) that is responsible for the production of T-toxin, a family of linear long-chain (C35 to E41) polyketides. In a previous study, the restriction enzyme-mediated integration procedure was used to mutagenize and tag Tox1. Here, we report that the DNA recovered from the insertion site of one mutant encodes a 7.6-kb open reading frame (2530 amino acids) that identifies a multifunctional polyketide synthase (PKS)-encoding gene (PKS1) with six catalytic domains arranged in the following order, starting at the N terminus: beta-ketoacyl synthase, acyltransferase, dehydratase, enoyl reductase, beta-ketoacyl reductase, and acyl carrier protein. PKS1 is interrupted by four apparent introns (74, 57, 49, and 41 bp) and exists in the genome as a single copy surrounded by highly repetitive, A + T-rich DNA. When PKS1 in race T was inactivated by targeted gene disruption, T-toxin production and high virulence were eliminated, indicating that this PKS is required for fungal virulence. Race O strains, which do not produce T-toxin, lack a detectable homolog of PKS1, suggesting that race T may have acquired PKS1 by horizontal transfer of DNA rather than by vertical inheritance from an ancestral strain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.