ArticleThe American journal of pathology1996
Expression of inducible nitric oxide synthase and its involvement in pulmonary granulomatous inflammation in rats.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 69 citations in OpenAlex.
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- Bosutinib Therapy Ameliorates Lung Inflammation and Fibrosis in Experimental Silicosis.Frontiers in physiology · 2017Article
- Acute and persisting Th2-like immune response after fractionated colorectal gamma-irradiation.World journal of gastroenterology · 2008Article
- Depression of T cell-mediated immunity reduces sulfadimethoxine-induced capsular inflammation and inhibits associated development of invasive thyroid follicular cell carcinomas in rats.Cancer science · 2007Article
- Effect of osteopontin alleles on beta-glucan-induced granuloma formation in the mouse liver.The American journal of pathology · 2004Article
- Protein nitration in cutaneous inflammation in the rat: essential role of inducible nitric oxide synthase and polymorphonuclear leukocytes.British journal of pharmacology · 2002Article
- Article
- Induction of haem oxygenase-1 nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth.British journal of cancer · 1999Article
- Expression of inducible nitric oxide synthase in human granulomas and histiocytic reactions.The American journal of pathology · 1999Article
- Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease.The Journal of clinical investigation · 1998Article
- Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation.Immunology · 1998Article
- Asbestos inhalation induces reactive nitrogen species and nitrotyrosine formation in the lungs and pleura of the rat.The Journal of clinical investigation · 1998Article
- Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice.Infection and immunity · 1997Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two types of pulmonary granulomatosis were produced in rats by intratracheal instillation of zymosan or silica. In both models, immunostaining with anti-rat monoclonal antibody for inducible nitric oxide synthase (iNOS), ANOS11, showed that the intensity of iNOS immunoreactivity in the inflammatory lesions peaked at 3 days and declined thereafter. Immunohistochemical double staining and in situ hybridization demonstrated the expression of iNOS in neutrophils, monocyte-derived macrophages, and bronchiolar epithelial cells in the pulmonary lesions. Electron spin resonance spectroscopy revealed the production of an excessive amount of nitric oxide (NO) in the pulmonary lesions. Immunostaining with a polyclonal antibody against nitrotyrosine indicated the formation of nitrotyrosine residues in the granulomatous lesions, particularly in the periphery of the lesions, providing indirect evidence for the generation of peroxynitrite anion in the zymosan- or silica-instilled lungs. Administration of N omega-nitro-L-arginine methyl ester or S-methylisothiourea sulfate, which significantly suppressed NO production, resulted in marked reduction of monocyte/macrophage infiltration as well as in inhibition of induction of monocyte chemoattractant protein-1 in the lesions. These data indicate that NO and its more reactive product peroxynitrite anion may be important mediators of granuloma formation in the lung.
Indexed as
Identifiers
8952535PMC1865352W77595489What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.