ArticleThe Journal of physiology1996
Localization of endothelin ETA and ETB receptor-mediated constriction in the renal microcirculation of rats.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 58 citations in OpenAlex.
- Mechanism of protective actions of sparsentan in the kidney: lessons from studies in models of chronic kidney disease.Clinical science (London, England : 1979) · 2024Review
- Quantifying the integrated physiological effects of endothelin-1 on cardiovascular and renal function in healthy subjects: a mathematical modeling analysis.Frontiers in pharmacology · 2024Article
- The acute pressure natriuresis response is suppressed by selective ETA receptor blockade.Clinical science (London, England : 1979) · 2021Article
- Endothelin contributes to blunted renal autoregulation observed with a high-salt diet.American journal of physiology. Renal physiology · 2015Article
- Endothelin Receptor Antagonists: New Hope for Renal Protection?Current hypertension reports · 2015Review
- Physiology of endothelin and the kidney.Comprehensive Physiology · 2011Review
- Regulation of blood pressure and salt homeostasis by endothelin.Physiological reviews · 2011Review
- ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo.American journal of physiology. Renal physiology · 2008Article
- ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelin.British journal of pharmacology · 2005Article
- Electrophysiological effects of endothelin-1 and their relationship to contraction in rat renal arterial smooth muscle.British journal of pharmacology · 2000Article
- Influence of endothelins and sarafotoxin 6c and L-NAME on renal vasoconstriction in the anaesthetized rat.British journal of pharmacology · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The aim of the study was to visualize endothelin-1 (ET-1)-mediated constriction in renal vessels of cortical and juxtamedullary glomeruli in the split hydronephrotic rat kidney in vivo and to functionally characterize the ET receptor subtypes involved. 2. ET-1 (10(-9) M) constricted preglomerular vessels (by 6-18%) and efferent arterioles (by 11-13%), and decreased glomerular blood flow (GBF, by 55%) of cortical and juxtamedullary glomeruli. 3. The ETA antagonist BQ-123 (10(-6) M), as well as the ETB antagonist BQ-788 (2 x 10(-7) M) and IRL 1038 (10(-6) M), shifted the concentration-response curve of GBF for ET-1 to the right by one order of magnitude. While BQ-123 antagonized ET-1 constriction only in preglomerular vessels, BQ-788 and IRL 1038 were effective both in preglomerular vessels and efferent arterioles. 4. The ETB agonist IRL 1620 (10(-8) M) reduced GBF by 50% and constricted efferent arterioles (by 20-33%) about two times more than preglomerular vessels (by 6-14%). 5. Our results suggest that in renal cortical and juxtamedullary vessels of rats, ET-1-induced preglomerular vasoconstriction is mediated by ETA and ETB receptors, while efferent vasoconstriction is predominantly mediated by ETB receptors, which might have important consequences for the regulation of glomerular filtration pressure by ET.
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