ArticleHistochemistry and cell biology1996
Regenerated rat fast muscle transplanted to the slow muscle bed and innervated by the slow nerve, exhibits an identical myosin heavy chain repertoire to that of the slow muscle.
Article in Histochemistry and cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- TGF-beta1 favors the development of fast type identity during soleus muscle regeneration.Journal of muscle research and cell motility · 2006Article
- "Fast" and "slow" muscle fibres in hindlimb muscles of adult rats regenerate from intrinsically different satellite cells.The Journal of physiology · 2005Article
- NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Changes in contractile activation characteristics of rat fast and slow skeletal muscle fibres during regeneration.The Journal of physiology · 2004Article
- Partial fast-to-slow conversion of regenerating rat fast-twitch muscle by chronic low-frequency stimulation.Journal of muscle research and cell motility · 2002Article
- Lack of coordinated changes in metabolic enzymes and myosin heavy chain isoforms in regenerated muscles of trained rats.Journal of muscle research and cell motility · 2000Article
- Myosin heavy chain profiles in regenerated fast and slow muscles innervated by the same motor nerve become nearly identical.The Histochemical journal · 1999Article
- Software for muscle fibre type classification and analysis.European journal of histochemistry : EJHArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypothesis that the limited adaptive range observed in fast rat muscles in regard to expression of the slow myosin is due to intrinsic properties of their myogenic stem cells was tested by examining myosin heavy chain (MHC) expression in regenerated rat extensor digitorum longus (EDL) and soleus (SOL) muscles. The muscles were injured by bupivacaine, transplanted to the SOL muscle bed and innervated by the SOL nerve. Three months later, muscle fibre types were determined. MHC expression in muscle fibres was demonstrated immunohistochemically and analysed by SDS-glycerol gel electrophoresis. Regenerated EDL transplants became very similar to the control SOL muscles and indistinguishable from the SOL transplants. Slow type 1 fibres predominated and the slow MHC-1 isoform was present in more than 90% of all muscle fibres. It contributed more than 80% of total MHC content in the EDL transplants. About 7% of fibres exhibited MHC-2a and about 7% of fibres coexpressed MHC-1 and MHC-2a. MHC-2x/d contributed about 5-10% of the whole MHCs in regenerated EDL and SOL transplants. The restricted adaptive range of adult rat EDL muscle in regard to the synthesis of MHC-1 is not rooted in muscle progenitor cells; it is probably due to an irreversible maturation-related change switching off the gene for the slow MHC isoform.
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Registered trials
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