ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie1996
Immunolocalization of basic fibroblast growth factor during wound repair in rat retina after laser photocoagulation.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 33 citations in OpenAlex.
- Prophylactic laser treatment in early age related maculopathy reduced the incidence of exudative complications.The British journal of ophthalmology · 1998Trial
- Subthreshold Nano-Second Laser Treatment and Age-Related Macular Degeneration.Journal of clinical medicine · 2021Review
- Changes in fibroblast growth factor-2 and FGF receptors in the frog visual system during optic nerve regeneration.Journal of chemical neuroanatomy · 2012Article
- Rearrangement of the cone mosaic in the retina of the rat model of retinitis pigmentosa.The Journal of comparative neurology · 2012Article
- Monocular focal retinal lesions induce short-term topographic plasticity in adult cat visual cortex.Proceedings. Biological sciences · 1999Article
- Immunolocalization of transforming growth factor beta during wound repair in rat retina after laser photocoagulation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1998Article
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Authors and funding
8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBasic fibroblast growth factor (bFGF) stimulates the mitogenesis of various cells and plays a key role in wound repair. We studied the immunohistochemical localization of bFGF during wound repair in the rat retina after laser photocoagulation.
methodsKrypton laser photocoagulation was performed on the eyes of pigmented rats. The eyes were enucleated on days 1, 3, 7, 14 and 28 after the photocoagulation, and the immunohistochemical localization of bFGF was assessed. Two different monoclonal antibodies and one polyclonal antibody against bFGF as first antibodies were used.
resultsMarked immunoreactivity for bFGF was found in the ganglion cell layer, and weak immunoreactivity for bFGF was found in the retinal pigment epithelial (RPE) cells of the normal adult rat retina. On day 3 after laser photocoagulation, the nuclei and cytoplasm of proliferating RPE cells at the center of the photocoagulated lesion showed intense bFGF immunoreactivity. The nuclei of RPE cells around the lesion showed intense bFGF immunoreactivity. Macrophages that migrated into the lesion showed positive staining for bFGF. These immunoreactivity decreased with time. Controls (0.05 M Tris-HCl buffer, normal serum, or these same antibodies preabsorbed with bFGF) did not show positive staining.
conclusionThe finding of an elevated expression of bFGF immunoreactivity in the photocoagulated lesion suggests that bFGF may play a role in wound repair in the rat retina after laser photocoagulation.
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