ArticleThe Biochemical journal1995
Prediction of O-glycosylation of mammalian proteins: specificity patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
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- Atheroprotective Effect of Fucoidan in THP-1 Macrophages by Potential Upregulation of ABCA1.Biomedicines · 2023Article
- Glycosylation of viral proteins: Implication in virus-host interaction and virulence.Virulence · 2022Review
- An Information Entropy-Based Approach for Computationally Identifying Histone Lysine Butyrylation.Frontiers in genetics · 2019Article
- O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic Trafficking.The Journal of biological chemistry · 2016Article
- Biological and biochemical properties of two Xenopus laevis N-acetylgalactosaminyltransferases with contrasting roles in embryogenesis.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2015Article
- Genetic analysis and antigenic characterization of human respiratory syncytial virus group A viruses isolated in Germany 1996-2008.Virus genes · 2013Article
- A novel model to predict O-glycosylation sites using a highly unbalanced dataset.Glycoconjugate journal · 2012Article
- Integrated mass spectrometry-based analysis of plasma glycoproteins and their glycan modifications.Nature protocols · 2011Article
- Support vector machine-based mucin-type o-linked glycosylation site prediction using enhanced sequence feature encoding.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2009Article
- Critical role of glycosylation in determining the length and structure of T cell epitopes.Immunome research · 2009Article
- Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007.Journal of clinical microbiology · 2009Article
- The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection.The Journal of biological chemistry · 2008Article
- Prediction of mucin-type O-glycosylation sites in mammalian proteins using the composition of k-spaced amino acid pairs.BMC bioinformatics · 2008Article
- Glycosylation site prediction using ensembles of Support Vector Machine classifiers.BMC bioinformatics · 2007Article
- Genetic variability in the G protein gene of group A and B respiratory syncytial viruses from India.Journal of clinical microbiology · 2006Article
- Oct-2 DNA binding transcription factor: functional consequences of phosphorylation and glycosylation.Nucleic acids research · 2006Article
- Organization, alternative splicing, polymorphism, and phylogenetic position of lamprey CD45 gene.Immunogenetics · 2005Article
- Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications.Protein science : a publication of the Protein Society · 2005Article
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Authors and funding
6 authors.
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Abstract
The specificity of the enzyme(s) catalysing the covalent link between the hydroxyl side chains of serine or threonine and the sugar moiety N-acetylgalactosamine (GalNAc) is unknown. Pattern recognition by artificial neural networks and weight matrix algorithms was performed to determine the exact position of in vivo O-linked GalNAc-glycosylated serine and threonine residues from the primary sequence exclusively. The acceptor sequence context for O-glycosylation of serine was found to differ from that of threonine and the two types were therefore treated separately. The context of the sites showed a high abundance of proline, serine and threonine extending far beyond the previously reported region covering positions -4 through +4 relative to the glycosylated residue. The O-glycosylation sites were found to cluster and to have a high abundance in the N-terminal part of the protein. The sites were also found to have an increased preference for three different classes of beta-turns. No simple consensus-like rule could be deduced for the complex glycosylation sequence acceptor patterns. The neural networks were trained on the hitherto largest data material consisting of 48 carefully examined mammalian glycoproteins comprising 264 O-glycosylation sites. For detection neural network algorithms were much more reliable than weight matrices. The networks correctly found 60-95% of the O-glycosylated serine/threonine residues and 88-97% of the non-glycosylated residues in two independent test sets of known glycoproteins. A computer server using E-mail for prediction of O-glycosylation sites has been implemented and made publicly available. The Internet address is NetOglyc@cbs.dtu.dk.
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