ArticleThe Biochemical journal1995
Kinetics of extracellular ATP hydrolysis by microvascular endothelial cells from rat heart.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity.Advances in pharmacology (San Diego, Calif.) · 2011Review
- Theoretical model of metabolic blood flow regulation: roles of ATP release by red blood cells and conducted responses.American journal of physiology. Heart and circulatory physiology · 2008Article
- Mathematical model of nucleotide regulation on airway epithelia. Implications for airway homeostasis.The Journal of biological chemistry · 2008Article
- Atorvastatin accelerates extracellular nucleotide degradation in human endothelial cells.Molecular and cellular biochemistry · 2008Article
- Extracellular metabolism of nucleotides in neuroblastoma x glioma NG108-15 cells determined by capillary electrophoresis.Cellular and molecular neurobiology · 2003Article
- The evidence for two opposite, ATP-generating and ATP-consuming, extracellular pathways on endothelial and lymphoid cells.The Biochemical journal · 2002Article
- Regulation of the ecto-nucleotidase pathway in rat hippocampal nerve terminals.Neurochemical research · 2001Article
- Cyclic GMP-dependent relaxation of isolated rat renal glomeruli induced by extracellular ATP.The Journal of physiology · 2001Article
- Role of A(2A)-adenosine receptor activation for ATP-mediated coronary vasodilation in guinea-pig isolated heart.British journal of pharmacology · 2000Article
- Effect of shear stress on the release of soluble ecto-enzymes ATPase and 5'-nucleotidase along with endogenous ATP from vascular endothelial cells.British journal of pharmacology · 2000Article
- T-tubule membranes from chicken skeletal muscle possess an enzymic cascade for degradation of extracellular ATP.The Biochemical journal · 1997Article
- The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.The Journal of clinical investigation · 1997Article
- Rabbit erythrocytes release ATP and dilate skeletal muscle arterioles in the presence of reduced oxygen tension.Pharmacological reports : PRArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have characterized the ectonucleotidases that catalyse the reaction sequence ATP-->ADP-->AMP-->adenosine on microvascular endothelial cells cultured from the rat heart. Computer simulation and data fitting of progress of reaction curves showed that depletion of substrate at the cell surface dominates the regulation of the rate of hydrolysis of ATP when it is presented to the cells. Preferential delivery of AMP by ADPase to 5'-nucleotidase makes a significant contribution to the regulation of adenosine production from ATP or ADP. By contrast, we found no evidence for the preferential delivery of ADP from ATPase to ADPase. Feed-forward inhibition of AMP hydrolysis by ADP and/or ATP also modulated the rate of adenosine production. The properties of the ectonucleotidases on rat heart microvascular cells are such that adenosine is produced at a steady rate over a wide range of ATP concentrations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.