ReviewNeurochemical research1996
Opioid receptors: some perspectives from early studies of their role in normal physiology, stress responsivity, and in specific addictive diseases.
Review in Neurochemical research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 86 citations in OpenAlex.
- Endometriosis and Opioid Receptors: Are Opioids a Possible/Promising Treatment for Endometriosis?International journal of molecular sciences · 2023Review
- Women in Neuroscience: Four Women's Contributions to Science and Society.Frontiers in integrative neuroscience · 2021Review
- Cold pressor pain and gambling disorder: implications for the opioid system.CNS spectrums · 2020Article
- Opioid use disorder.Nature reviews. Disease primers · 2020Review
- The Neurobiology Shaping Affective Touch: Expectation, Motivation, and Meaning in the Multisensory Context.Frontiers in psychology · 2015Review
- Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents.Alcoholism, clinical and experimental research · 2013Article
- Regulation of mammalian MOR-1 gene expression after chronic treatment with morphine.International journal of molecular medicine · 2012Article
- Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine.Molecular medicine reports · 2012Article
- Neurotransmitter and neuromodulator genes associated with a history of depressive symptoms in individuals with alcohol dependence.Alcoholism, clinical and experimental research · 2011Article
- Exposure to cocaine alters dynorphin-mediated regulation of excitatory synaptic transmission in nucleus accumbens neurons.Biological psychiatry · 2011Article
- Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism.Substance use & misuse · 2010Review
- Drug-induced and genetic alterations in stress-responsive systems: Implications for specific addictive diseases.Brain research · 2010Review
- Polymorphisms of the mu-opioid receptor and dopamine D4 receptor genes and subjective responses to alcohol in the natural environment.Journal of abnormal psychology · 2010Article
- Initial evidence of an association between OPRM1 and adolescent alcohol misuse.Alcoholism, clinical and experimental research · 2010Article
- Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians.BMC medical genetics · 2008Article
- Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.Neuroscience · 2007Article
- Morphine and pain-related stimuli enhance cell surface availability of somatic delta-opioid receptors in rat dorsal root ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction.Pharmacogenetics · 2004Article
- Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats.Psychopharmacology · 2004Article
- Morphine-induced changes in delta opioid receptor trafficking are linked to somatosensory processing in the rat spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The early history of research on the possible existence of specific opioid receptors and on developing a new form of pharmacotherapy for the treatment of heroin addiction in New York City, from 1960-1973, along with the special relationships between two leading scientists conducting these research efforts, Dr. Eric Simon and Dr. Vincent P. Dole Jr., are presented in a historical perspective. The linkage of these early efforts and the subsequent identification and the elucidation of the effects of exogenous opiates acting at specific opiate receptors in human physiology, including some findings from perspective studies of heroin addicts at time of entry to and during methadone maintenance treatment, are presented in the context of the important clues which thereby were provided concerning the possible roles of the endogenous opioids in normal mammalian physiology. From many of these early clinical research findings and studies in animal models, the hypothesis that the endogenous opioids system may play an important role in stress responsivity was formulated along with the related hypothesis, first presented in the early 1970s, that an atypical responsivity to stress and stressors might be involved in the acquisition and persistence of, and relapse to specific addictive diseases, including heroin addiction, cocaine dependency and alcoholism. More recent studies of the possible involvement of the specific opioid receptors in these three addictive diseases-heroin addiction, cocaine addiction and alcoholism-from our laboratory are discussed in a historical perspective of the development of these ideas from the early research findings of not only Dr. Eric Simon, but his numerous colleagues in opioid research in the United States and throughout the world.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.