ArticleThe Biochemical journal1996
Extracellular high-mobility group 1 protein is essential for murine erythroleukaemia cell differentiation.
Article in The Biochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- RNA N4-acetylcytidine modification in human cancers: from molecular function to oncogenic mechanisms.iScience · 2026Review
- Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies.Journal of hematology & oncology · 2020Review
- Proinflammatory Effects of Respiratory Syncytial Virus-Induced Epithelial HMGB1 on Human Innate Immune Cell Activation.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- HMGB1 in health and disease.Molecular aspects of medicine · 2014Review
- The role of high mobility group box 1 in innate immunity.Yonsei medical journal · 2014Review
- Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein.PloS one · 2012Article
- Calcium/calmodulin-dependent protein kinase (CaMK) Ialpha mediates the macrophage inflammatory response to sepsis.Journal of leukocyte biology · 2011Article
- HMGb1 promotes scratch wound closure of HaCaT keratinocytes via ERK1/2 activation.Molecular and cellular biochemistry · 2009Article
- Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- HMGB1 as an autocrine stimulus in human T98G glioblastoma cells: role in cell growth and migration.Journal of neuro-oncology · 2008Article
- Activation of A431 human carcinoma cell motility by extracellular high-mobility group box 1 protein and epidermal growth factor stimuli.The Biochemical journal · 2005Article
- Native versus recombinant high-mobility group B1 proteins: functional activity in vitro.Inflammation · 2004Article
- Stimulation of erythroleukaemia cell differentiation by extracellular high-mobility group-box protein 1 is independent of the receptor for advanced glycation end-products.The Biochemical journal · 2002Article
- New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal.The EMBO journal · 2001Review
- Extracellular processing of amphoterin generates a peptide active on erythroleukaemia cell differentiation.The Biochemical journal · 2001Article
- The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells.The Journal of cell biology · 2001Article
- Targeting HMGB1 in inflammation.Biochimica et biophysica actaReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A high-mobility group 1 (HMG1) protein type isolated from murine erythroleukaemia (MEL) cells promotes acceleration of the differentiation process when added to a MEL cell culture together with the inducer hexamethylene bisacetamide. We now provide direct evidence that the presence of HMG1 protein in the extracellular medium is essential for terminal erythroid differentiation. An extracellular function for HMG1 protein in MEL cell is further supported by a demonstration that this protein is released from MEL cells exposed to the chemical inducer and that the addition of an anti-(HMG1 protein) monoclonal antibody to the cell culture inhibits the differentiation process almost completely. The release of HMG1 protein from MEL cells is modulated by compounds affecting cell calcium homoeostasis, such as a calcium ionophore or verapamil. In fact, in the presence of the ionophore an increased rate of differentiation is accompanied by an enhanced extracellular release of HMG1 protein, whereas in the presence of verapamil both phenomena are significantly decreased.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.