ArticleThe EMBO journal1996
A locus control region at -12 kb of the tyrosinase gene.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 84 citations in OpenAlex.
- Evolved Bmp6 enhancer alleles drive spatial shifts in gene expression during tooth development in sticklebacks.Genetics · 2021Article
- Boundary sequences flanking the mouse tyrosinase locus ensure faithful pattern of gene expression.Scientific reports · 2020Article
- Epigenetic mechanisms in health and disease: BCEC 2017.Epigenetics · 2018Article
- Functional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR-Cas9-mediated mutagenesis.Nucleic acids research · 2015Article
- Mendel: a simple excel workbook to compare the observed and expected distributions of genotypes/phenotypes in transgenic and knockout mouse crosses involving up to three unlinked loci by means of a χ2 test.Transgenic research · 2012Article
- Expression of the E3L gene of vaccinia virus in transgenic mice decreases host resistance to vaccinia virus and Leishmania major infections.Journal of virology · 2008Article
- A strategy to study tyrosinase transgenes in mouse melanocytes.BMC cell biology · 2005Article
- The potential benefits of insulators on heterologous constructs in transgenic animals.Transgenic research · 2003Article
- Tyrosinase gene mutations in oculocutaneous albinism 1 (OCA1): definition of the phenotype.Human genetics · 2003Article
- Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activity.Nucleic acids research · 2003Article
- Size matters: use of YACs, BACs and PACs in transgenic animals.Transgenic research · 2001Review
- Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock.Molecular and cellular biology · 2000Article
- Transcription of genes encoding pregnancy-specific glycoproteins is regulated by negative promoter-selective elements.The Biochemical journal · 2000Article
- Enhancer blocking by the Drosophila gypsy insulator depends upon insulator anatomy and enhancer strength.Genetics · 1999Article
- Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Molecular and cellular biology · 1999Article
- Dividing the empire: boundary chromatin elements delimit the territory of enhancers.The EMBO journal · 1999Review
- Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development.The EMBO journal · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have shown previously that the tyrosinase gene encompassed in a 250 kb yeast artificial chromosome (YAC) is expressed faithfully in transgenic mice. To define the sequences important for this qualitatively and quantitatively correct expression pattern, we have generated transgenic mice with YACs carrying several deletions in the mouse tyrosinase locus. In particular, we wanted to address the in vivo relevance of a regulatory element indicated by a cell-specific DNase I hypersensitive site (HS) located -12 kb upstream of the gene. Wild-type level expression was observed only when the YACs transferred contained this HS. Constructs in which the HS was deleted gave rise to much weaker expression and variable patterns of expression. In conclusion, this HS region appears to harbour the essential regulatory element for the correct expression of the tyrosinase gene. Moreover, it behaves as a locus control region in that it commands the functional status of this expression domain, protecting it from position effects.
Indexed as
Identifiers
8947025PMC452424W1431639342What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.