ArticleInfection and immunity1996
Disruption of the SNF1 gene abolishes trehalose utilization in the pathogenic yeast Candida glabrata.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Multilayered control of hexose uptake and phosphorylation through specialized sugar kinases in Nakaseomyces glabratus.Fungal biology and biotechnology · 2026Article
- Sugar Sensing and Signaling inFrontiers in microbiology · 2019Review
- Snf1 is a regulator of lipid accumulation in Yarrowia lipolytica.Applied and environmental microbiology · 2013Article
- Expression plasmids for use in Candida glabrata.G3 (Bethesda, Md.) · 2013Article
- Candida glabrata environmental stress response involves Saccharomyces cerevisiae Msn2/4 orthologous transcription factors.Molecular microbiology · 2008Article
- Biology of the pathogenic yeast Candida glabrata.Folia microbiologica · 2006Review
- Loss of function of the Fusarium oxysporum SNF1 gene reduces virulence on cabbage and Arabidopsis.Current genetics · 2003Article
- The Cochliobolus carbonum SNF1 gene is required for cell wall-degrading enzyme expression and virulence on maize.The Plant cell · 2000Article
- Isolation of the MIG1 gene from Candida albicans and effects of its disruption on catabolite repression.Journal of bacteriology · 2000Article
- Isolation of Candida glabrata homologs of the Saccharomyces cerevisiae KRE9 and KNH1 genes and their involvement in cell wall beta-1,6-glucan synthesis.Journal of bacteriology · 1998Article
- A gene homologous to Saccharomyces cerevisiae SNF1 appears to be essential for the viability of Candida albicans.Infection and immunity · 1997Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SNF1 gene product, a serine/threonine protein kinase, is a global regulatory protein which has been isolated from several organisms. In Saccharomyces cerevisiae the SNF1 gene product is essential for the derepression of glucose repression since snf1 strains are unable to utilize sucrose, galactose, maltose, melibiose, or nonfermentable carbohydrates. Moreover, the SNF1 gene product was suggested to interact with additional regulatory pathways and to affect the expression of multiple target genes as reflected by the pleiotropic nature of the snf1 mutation. Here we report the characterization of the SNF1 homolog of Candida glabrata, a pathogenic yeast phylogenetically related to S. cerevisiae. The carbon utilization spectrum of C. glabrata is considerably narrower than that of other pathogenic yeasts, and the majority of the strains utilize solely glucose and trehalose from among 20 of the most commonly tested carbohydrates. Disruption of the C. glabrata SNF1 homolog resulted in the loss of the ability to utilize trehalose, indicating that even in an organism with such a limited carbon utilization spectrum, the regulatory mechanism governing catabolic repression is preserved.
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