ArticleInfection and immunity1996
Binding of extracellular matrix proteins to Aspergillus fumigatus conidia.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 81 citations in OpenAlex.
- The role of melanin inFuture microbiology · 2025Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Review
- Aspergillus fumigatus adhesion factors in dormant conidia revealed through comparative phenotypic and transcriptomic analyses.Cellular microbiology · 2018Article
- Systems Biology Approaches for Host-Fungal Interactions: An Expanding Multi-Omics Frontier.Omics : a journal of integrative biology · 2016Review
- Interactions of Aspergillus fumigatus Conidia with Airway Epithelial Cells: A Critical Review.Frontiers in microbiology · 2016Review
- Identification of fibrinogen-binding proteins of Aspergillus fumigatus using proteomic approach.Mycopathologia · 2012Article
- Phage display against corneal epithelial cells produced bioactive peptides that inhibit Aspergillus adhesion to the corneas.PloS one · 2012Article
- Molecular mechanism of Aspergillus fumigatus adherence to host constituents.Current opinion in microbiology · 2011Review
- Development of a novel ex vivo model of corneal fungal adherence.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2011Article
- Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidia.BMC microbiology · 2009Article
- Purification and partial characterization of a Paracoccidioides brasiliensis protein with capacity to bind to extracellular matrix proteins.Infection and immunity · 2005Article
- Purification and partial characterization of a 32-kilodalton sialic acid-specific lectin from Aspergillus fumigatus.Infection and immunity · 2002Article
- A parasitic phase-specific adhesin of Coccidioides immitis contributes to the virulence of this respiratory Fungal pathogen.Infection and immunity · 2002Article
- Human immunodeficiency virus type 1 Tat binds to Candida albicans, inducing hyphae but augmenting phagocytosis in vitro.Immunology · 2001Article
- Involvement of fungal cell wall components in adhesion of Sporothrix schenckii to human fibronectin.Infection and immunity · 2001Article
- Article
- Adhesion of Aspergillus species to extracellular matrix proteins: evidence for involvement of negatively charged carbohydrates on the conidial surface.Infection and immunity · 2000Article
- Recognition of fibronectin by Penicillium marneffei conidia via a sialic acid-dependent process and its relationship to the interaction between conidia and laminin.Infection and immunity · 1999Article
- Aspergillus fumigatus and aspergillosis.Clinical microbiology reviews · 1999Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As detected by confocal immunofluorescence microscopy, binding of fibronectin and laminin appeared to be associated with the protrusions present on the outer cell wall layer of resting Aspergillus fumigatus conidia. Flow cytometry confirmed that binding of laminin to conidia was dose dependent and saturable. Laminin binding was virtually eliminated in trypsin-treated organisms, thus suggesting the protein nature of the binding site. Conidia were also able to specifically adhere to laminin immobilized on microtiter plates. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting (immunoblotting) with laminin and antilaminin antibody of whole conidial homogenates allowed identification, among the complex array of protein and glycoprotein species, of one polypeptide with an apparent molecular mass of 37 kDa which specifically interacts with laminin. The fact that binding of conidia to soluble or immobilized laminin or fibronectin was inhibited by fibronectin or laminin, respectively, suggests the existence of common binding sites for both ligands on the surface of conidia. Intact conidia were also able to adhere to type I and IV collagen immobilized on microtiter plates; adhesion was found to be dose dependent and saturable. Adhesion to immobilized type I and IV collagen was markedly inhibited by laminin and weakly inhibited by fibronectin. Coincubation of conidia with Arg-Gly-Asp (RGD) peptides caused a dose-dependent decrease in binding of cells to immobilized or soluble fibronectin, yet interaction of cells with soluble or immobilized laminin and type I and IV collagen remained unaffected. Interactions described here could be important in mediating attachment of the fungus to host tissues, thus playing a role in the establishment of the disease.
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