ArticleInfection and immunity1996
Migration of the fungal pathogen Candida albicans across endothelial monolayers.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Trans-cellular tunnels induced by the fungal pathogen Candida albicans facilitate invasion through successive epithelial cells without host damage.Nature communications · 2022Article
- A genome-wide transcriptional analysis of morphology determination in Candida albicans.Molecular biology of the cell · 2013Article
- Aimless mutants of Cryptococcus neoformans: failure to disseminate.Fungal biology reviews · 2012Article
- Coevolution of morphology and virulence in Candida species.Eukaryotic cell · 2011Review
- A review of the ultrastructural features of superficial candidiasis.Mycopathologia · 2011Review
- The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils.Infection and immunity · 2009Article
- The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferation.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- UME6, a novel filament-specific regulator of Candida albicans hyphal extension and virulence.Molecular biology of the cell · 2008Article
- Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases.Infection and immunity · 2005Article
- Borrelia burgdorferi, host-derived proteases, and the blood-brain barrier.Infection and immunity · 2005Article
- Strategies for the identification of virulence determinants in human pathogenic fungi.Current genetics · 2003Review
- Candida albicans expresses a focal adhesion kinase-like protein that undergoes increased tyrosine phosphorylation upon yeast cell adhesion to vitronectin and the EA.hy 926 human endothelial cell line.Infection and immunity · 2002Article
- Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs.Infection and immunity · 2002Article
- Traversal of Candida albicans across human blood-brain barrier in vitro.Infection and immunity · 2001Article
- Morphogenesis, adhesive properties, and antifungal resistance depend on the Pmt6 protein mannosyltransferase in the fungal pathogen candida albicans.Journal of bacteriology · 2000Article
- Epithelial responses and Candida albicans pathogenicity are enhanced in the presence of oral streptococci.Brazilian dental journalArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migration of the fungal pathogen Candida albicans across the endothelial cell layer is considered a prerequisite for the invasion of multiple organs occurring in systemic candidiasis. We developed an experimental system in which C. albicans migrates from a luminal compartment across a monolayer of bovine aortic endothelial cells on a porous filter support to an abluminal compartment. In this system, a C. albicans wild-type strain (ATCC 10261) traverses the endothelial monolayer in a time-, glucose-, and cell concentration-dependent manner. A mutant derivative unable to grow and form hyphae (SGY-243) migrates at a reduced rate. Concomitant to transendothelial migration, the permeability of the endothelial monolayer for dextran diffusion markers is significantly increased. This increase in transendothelial exchange occurs before fungal cells are detectable in the abluminal compartment and is time, glucose, and cell concentration dependent. A mutant strain (hOG301) unable to interact with endothelial cells does not alter endothelial permeability. Thus, transendothelial migration of C. albicans is able to damage the barrier function of an endothelial monolayer. Our experimental system, which reflects key stages of transendothelial migration of C. albicans including adherence and passage across endothelial cells and the extracellular matrix, may be a useful model for comparisons of transendothelial migration characteristics of Candida strains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.