ArticleInfection and immunity1996
Evidence for apoptosis of human macrophage-like HL-60 cells by Legionella pneumophila infection.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 114 citations in OpenAlex.
- Identification of differentially expressedHeliyon · 2020Article
- In vitro and intracellular activities of frog skin temporins against Legionella pneumophila and its eukaryotic hosts.Scientific reports · 2020Article
- Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts.Frontiers in cell and developmental biology · 2020Article
- Morphology-based classification of mycobacteria-infected macrophages with convolutional neural network: reveal EsxA-induced morphologic changes indistinguishable by naked eyes.Translational research : the journal of laboratory and clinical medicine · 2019Article
- Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages.PLoS pathogens · 2016Article
- Influence of the Paracoccidioides brasiliensis 14-3-3 and gp43 proteins on the induction of apoptosis in A549 epithelial cells.Memorias do Instituto Oswaldo Cruz · 2015Article
- Midazolam induces cellular apoptosis in human cancer cells and inhibits tumor growth in xenograft mice.Molecules and cells · 2013Article
- Hyperoxia accelerates Fas-mediated signaling and apoptosis in the lungs of Legionella pneumophila pneumonia.BMC research notes · 2011Article
- Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Article
- Temporal and spatial trigger of post-exponential virulence-associated regulatory cascades by Legionella pneumophila after bacterial escape into the host cell cytosol.Environmental microbiology · 2010Article
- Transcriptional down-regulation and rRNA cleavage in Dictyostelium discoideum mitochondria during Legionella pneumophila infection.PloS one · 2009Article
- The Legionella pneumophila replication vacuole: making a cosy niche inside host cells.Nature reviews. Microbiology · 2009Review
- Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone.Respiratory research · 2008Article
- Host-dependent trigger of caspases and apoptosis by Legionella pneumophila.Infection and immunity · 2007Article
- Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection.The Journal of experimental medicine · 2006Article
- Incomplete activation of macrophage apoptosis during intracellular replication of Legionella pneumophila.Infection and immunity · 2005Article
- Chlamydia inhibit host cell apoptosis by degradation of proapoptotic BH3-only proteins.The Journal of experimental medicine · 2004Article
- Acanthamoeba spp. as agents of disease in humans.Clinical microbiology reviews · 2003Review
- Intracellular growth of Legionella pneumophila gives rise to a differentiated form dissimilar to stationary-phase forms.Infection and immunity · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legionella pneumophila, the causative agent of Legionnaires' disease and Pontiac fever, replicates within and eventually kills human macrophages. In this study, we show that L. pneumophila is cytotoxic to HL-60 cells, a macrophage-like cell line. We demonstrate that cell death mediated by L. pneumophila occurred at least in part through apoptosis, as shown by changes in nuclear morphology, an increase in the proportion of fragmented host cell DNA, and the typical ladder pattern of DNA fragmentation indicative of apoptosis. We further sought to determine whether potential virulence factors like the metalloprotease and the macrophage infectivity potentiator of L. pneumophila are involved in the induction of apoptosis. None of these factors are essential for the induction of apoptosis in HL-60 cells but may be involved in other cytotoxic mechanisms that lead to accidental cell death (necrosis). The ability of L. pneumophila to promote cell death may be important for the initiation of infection, bacterial survival, and escape from the host immune response. Alternatively, the triggering of apoptosis in response to bacterial infection may have evolved as a means of the host immune system to reduce or inhibit bacterial replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.