ArticleGut1996
Relation between gastric acid output, Helicobacter pylori, and gastric metaplasia in the duodenal bulb.
Article in Gut, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 70 citations in OpenAlex.
- Molecular Imaging Studies of Alcohol Use Disorder.Current topics in behavioral neurosciences · 2025Review
- Review
- Non-atrophic gastric mucosa is an independently associated factor for superficial non-ampullary duodenal epithelial tumors: a multicenter, matched, case-control study.Clinical endoscopy · 2023Article
- Duodenal Gastric Metaplasia and Duodenal Neuroendocrine Neoplasms: More Than a Simple Coincidence?Journal of clinical medicine · 2022Article
- Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.PloS one · 2021Article
- The different pathogeneses of sporadic adenoma and adenocarcinoma in non-ampullary lesions of the proximal and distal duodenum.Oncotarget · 2017Article
- Inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum.World journal of gastroenterology · 2007Article
- Gastric duodenal metaplasia in duodenal adenomas.Journal of clinical pathology · 2007Article
- Immunological and morphogenic basis of gastric mucosa atrophy and metaplasia.Virchows Archiv : an international journal of pathology · 2005Review
- A simple method to demonstrate duodenal gastric metaplasia.Journal of clinical pathology · 2002Article
- Mechanisms involved in Helicobacter pylori induced duodenal ulcer disease:an overview.World journal of gastroenterology · 2000Article
- Effect of Helicobacter pylori eradication on 24-hour gastric pH and duodenal gastric metaplasia.Digestive diseases and sciences · 2000Article
- The pathogenesis of duodenal gastric metaplasia: the role of local goblet cell transformation.Gut · 2000Article
- [1997 gastroenterology update--I].Medizinische Klinik (Munich, Germany : 1983) · 1998Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFactors that determine gastric metaplasia in the duodenal bulb are ill defined. It is more common and extensive in the presence of high acid output and possibly in the presence of Helicobacter pylori. However, no quantitative relation between acid output and the extent of gastric metaplasia has been demonstrated and its relation to H pylori is uncertain.
aimTo determine the relation between H pylori infection and acid output and the presence and extent of gastric metaplasia in the duodenal bulb. subjects: H pylori positive and negative patients with duodenal ulcer and healthy controls were studied.
methodsQuadrantic duodenal bulb biopsy specimens were taken and the presence and extent of gastric metaplasia determined using a computer enhanced image intensifier. Basal and stimulated acid outputs were measured.
resultsgastric metaplasia was significantly (p < 0.05 more common and significantly (p < 0.05) greater in extent in patients with duodenal ulcer than in controls. Neither the prevalence or extent of gastric metaplasia was affected by H pylori status. There were significant (p < 0.01) direct correlations between acid output and extent of gastric metaplasia.
conclusionsPrevalence and extent of gastric metaplasia are not related to H pylori in controls, or in patients with duodenal ulcer. Rather, high acid response to gastrin may be more important.
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