ArticleImmunology1996
The involvement of nitric oxide in the anti-Candida albicans activity of rat neutrophils.
Article in Immunology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 60 citations in OpenAlex.
- Potential Anti-International journal of molecular sciences · 2023Article
- Conservative Mechanisms of Extracellular Trap Formation by Annelida Eisenia andrei: Serine Protease Activity Requirement.PloS one · 2016Article
- Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects.Iranian journal of basic medical sciences · 2014Review
- Nitric oxide and nitrosative stress tolerance in yeast.Biochemical Society transactions · 2011Article
- Arginine-induced germ tube formation in Candida albicans is essential for escape from murine macrophage line RAW 264.7.Infection and immunity · 2009Article
- Nitric oxide plays a key role in the platelet-activating factor-induced enhancement of resistance against systemic candidiasis.Immunology · 2008Article
- Complement-induced Impairment of the Innate Immune System During Sepsis.Current infectious disease reports · 2005Article
- Regulation of fungal infection by a combination of amphotericin B and peptide 2, a lactoferrin peptide that activates neutrophils.Clinical and diagnostic laboratory immunology · 2004Article
- Complement-induced impairment of the innate immune system during sepsis.Current allergy and asthma reports · 2004Review
- Nitric oxide-enhanced resistance to oral candidiasis.Immunology · 2001Article
- Lactoferrin peptide increases the survival of Candida albicans-inoculated mice by upregulating neutrophil and macrophage functions, especially in combination with amphotericin B and granulocyte-macrophage colony-stimulating factor.Infection and immunity · 2001Article
- Virulence of Sporothrix schenckii conidia and yeast cells, and their susceptibility to nitric oxide.Immunology · 2000Article
- Effect of peroxynitrite on dormant spores and germlings of Aspergillus fumigatus in vitro.Folia microbiologica · 2000Article
- Cytokine regulation on the synthesis of nitric oxide in vivo by chronically infected human polymorphonuclear leucocytes.Immunology · 1998Article
- Nitric oxide is required for effective innate immunity against Klebsiella pneumoniae.Infection and immunity · 1997Article
- A review on the inhibitory potential of Nigella sativa against pathogenic and toxigenic fungi.Avicenna journal of phytomedicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rat peritoneal neutrophils (PMN) spontaneously release nitric oxide (NO) when incubated in vitro. Addition of the NO synthase inhibitor L-monomethylarginine (L-NMMA) to the PMN reduces NO production and impairs the killing of the yeast Candida albicans, both effects being reversed by L-arginine. These data strongly suggest that oxidative metabolism of L-arginine by PMN is involved in the candidacidal activity of these cells. Rat blood PMN, which do not produce significant amounts of NO, exhibit a reduced killing capacity compared with peritoneal cells, except when they are obtained from lipopolysaccharide (LPS)-treated rats. In this case they produce measurable amounts of nitrite and express high fungicidal activity in vitro. Confirming the candidacidal activity of NO, the exposure of the C. albicans cultures to different concentrations of NO donors leads to a reduction in their survival. The candidacidal activity related to the NO pathway in rat PMN is phagocytosis dependent, since the activity can be inhibited by cytochalasin B. However, the oxidative products of oxygen released by rat PMN do not seem to be involved in their candidacidal activity, as incubation of the cells with phorbol myristate acetate (PMA) increases release of superoxide anion but does not affect the pattern of killing. Our results suggest that NO could be an important candidacidal pathway in rat neutrophils.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.