ArticleMolecular and cellular biology1996
The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 67 citations in OpenAlex.
- Retinoblastoma protein activity revealed by CRISPRi study of divergent Rbf1 and Rbf2 paralogs.G3 (Bethesda, Md.) · 2024Article
- The Function of Lipin in the Wing Development ofInternational journal of molecular sciences · 2019Article
- Posttranslational modifications of the retinoblastoma tumor suppressor protein as determinants of function.Genes & cancer · 2012Article
- The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle.Cell division · 2012Article
- Article
- Evaluation of E1A double mutant oncolytic adenovectors in anti-glioma gene therapy.Journal of medical virology · 2008Article
- Limited redundancy in phosphorylation of retinoblastoma tumor suppressor protein by cyclin-dependent kinases in acute lymphoblastic leukemia.The American journal of pathology · 2006Article
- Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferase.Molecular and cellular biology · 2001Article
- Role of the LXCXE binding site in Rb function.Molecular and cellular biology · 2000Article
- Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Cumulative effect of phosphorylation of pRB on regulation of E2F activity.Molecular and cellular biology · 1999Article
- Article
- The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation.Molecular and cellular biology · 1997Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Progression through the cell cycle is dependent on the sequential expression of cyclins, which combine with cyclin-dependent kinases (cdks) to form active kinases. The transition from G1 to S phase is dependent on D cyclins in complex with cdk4 or cdk6 and cyclin E complexed with cdk2. One target of G1 cyclins is the retinoblastoma susceptibility protein (Rb). Rb is a transcriptional repressor that is selectively targeted to genes through interaction with the E2F family of cell cycle transcription factors. Rb is a member of a family of proteins that include p107 and p130. The three proteins share a region known as the pocket that is important for binding E2F and is also the binding site for oncoproteins from DNA tumor viruses that inactivate Rb. We have found that two conserved domains within the Rb pocket (A and B) interact to form a transcriptional repressor motif (K. N. B. Chow and D. C. Dean, Mol. Cell. Biol. 16:4862-4868, 1996). Here we demonstrate that p107 also has an A-B repressor motif, and using domain swapping and coimmunoprecipitation assays, we compare A and B from Rb and p107. Finally and most importantly, we demonstrate that the A-B interaction which forms the repressor motif is blocked by G1 cdk phosphorylation, thereby blocking repressor activity. This A-B repressor motif is then the first example of a cdk-regulated transcriptional repressor.
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