ArticleMolecular and cellular biology1996
The kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localization.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Three new compounds with nitric oxide inhibitory activity fromBMC chemistry · 2019Article
- Regulation of T cell development by c-Cbl: essential role of Lck.International immunology · 2015Article
- Molecular characterization, tissue expression, polymorphism and association of porcine LCK gene.Molecular biology reports · 2012Article
- How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism.Frontiers in immunology · 2012Article
- RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.PloS one · 2010Article
- T-cell receptor signaling is mediated by transient Lck activity, which is inhibited by inorganic mercury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells.The Biochemical journal · 2003Article
- Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes.Molecular and cellular biology · 2001Article
- Review
- Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts.Oncogene · 2000Article
- Adhesion to fibronectin promotes the activation of the p125(FAK)/Zap-70complex in human T cells.Immunology · 1999Article
- Interleukin 2-mediated uncoupling of T cell receptor alpha/beta from CD3 signaling.The Journal of experimental medicine · 1998Article
- Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases.Molecular and cellular biology · 1998Article
- T cell receptor (TCR) engagement in apoptosis-defective, but interleukin 2 (IL-2)-producing, T cells results in impaired ZAP70/CD3-zeta association.The Journal of experimental medicine · 1998Article
- ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domains.The Journal of cell biology · 1997Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antigenic stimulation of the T-cell antigen receptor initiates signal transduction through the immunoreceptor tyrosine-based activation motifs (ITAMs). When its two tyrosines are phosphorylated, ITAM forms a binding site for ZAP-70, one of the cytoplasmic protein tyrosine kinases essential for T-cell activation. The signaling process that follows ZAP-70 binding to ITAM has been analyzed by the construction of fusion proteins that localize ZAP-70 to the plasma membrane. We found that membrane-localized forms of ZAP-70 induce late signaling events such as activation of nuclear factor of activated T cells without any stimulation. This activity was observed only when Lck was expressed and functional. In addition, each mutation that affects the function of Lck in the kinase, Src homology 2 (SH2), and SH3 domains greatly impaired the signaling ability of the chimeric protein. Therefore, Lck functions in multiple manners in T-cell activation for the steps following ZAP-70 binding to ITAM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.