ArticleMolecular and cellular biology1996
p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
51 citing papers in PubMed, 112 citations in OpenAlex.
- Genome-wide screening in human embryonic stem cells identifies genes and pathways involved in the p53 pathway.Molecular medicine (Cambridge, Mass.) · 2025Article
- Alternate Roles of Sox Transcription Factors beyond Transcription Initiation.International journal of molecular sciences · 2021Review
- TATA-Like Boxes in RNA Polymerase III Promoters: Requirements for Nucleotide Sequences.International journal of molecular sciences · 2020Article
- 40 Years of Research Put p53 in Translation.Cancers · 2018Review
- Translation Control byCancers · 2018Article
- Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements.Cell cycle (Georgetown, Tex.) · 2018Article
- The RNA polymerase III subunit Polr3b is required for the maintenance of small intestinal crypts in mice.Cellular and molecular gastroenterology and hepatology · 2016Article
- Gender Specific Differences in RNA Polymerase III Transcription.Journal of carcinogenesis & mutagenesis · 2016Article
- Review
- Overexpression of TFIIB-related factor 2 is significantly correlated with tumor angiogenesis and poor survival in patients with esophageal squamous cell cancer.Medical oncology (Northwood, London, England) · 2013Article
- Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases.The Journal of biological chemistry · 2012Article
- RNA polymerase III transcription in cancer: the BRF2 connection.Molecular cancer · 2011Review
- Impact of Alu repeats on the evolution of human p53 binding sites.Biology direct · 2011Article
- Genome stability control by checkpoint regulation of tRNA gene transcription.Transcription · 2010Article
- Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription.Cell cycle (Georgetown, Tex.) · 2010Review
- Transcriptional regulation by p53.Cold Spring Harbor perspectives in biology · 2010Review
- Review
- TLS inhibits RNA polymerase III transcription.Molecular and cellular biology · 2010Article
- Article
- Differential expression of the TFIIIB subunits Brf1 and Brf2 in cancer cells.BMC molecular biology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Wild-type p53 represses Alu template activity in vitro and in vivo. However, upstream activating sequence elements from both the 7SL RNA gene and an Alu source gene relieve p53-mediated repression. p53 also represses the template activity of the U6 RNA gene both in vitro and in vivo but has no effect on in vitro transcription of genes encoding 5S RNA, 7SL RNA, adenovirus VAI RNA, and tRNA. The N-terminal activation domain of p53, which binds TATA-binding protein (TBP), is sufficient for repressing Alu transcription in vitro, and mutation of positions 22 and 23 in this region impairs p53-mediated repression of an Alu template both in vitro and in vivo. p53's N-terminal domain binds TFIIIB, presumably through its known interaction with TBP, and mutation of positions 22 and 23 interferes with TFIIIB binding. These results extend p53's transcriptional role to RNA polymerase III-directed templates and identify an additional level of Alu transcriptional regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.