ArticleMolecular and cellular biology1996
Phosphorylation of E47 as a potential determinant of B-cell-specific activity.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 98 citations in OpenAlex.
- Targeting TNF/IL-17/MAPK pathway in hHaematologica · 2024Article
- Multi-site phosphorylation controls the neurogenic and myogenic activity of E47.Biochemical and biophysical research communications · 2019Article
- Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer.Oncogene · 2016Article
- E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease.Developmental cell · 2015Review
- Molecular Framework of a Regulatory Circuit Initiating Two-Dimensional Spatial Patterning of Stomatal Lineage.PLoS genetics · 2015Article
- Functional redundancy between the transcriptional activation domains of E2A is mediated by binding to the KIX domain of CBP/p300.Nucleic acids research · 2014Article
- B-lineage transcription factors and cooperating gene lesions required for leukemia development.Leukemia · 2013Review
- Tcf15 primes pluripotent cells for differentiation.Cell reports · 2013Article
- E47 and Id1 interplay in epithelial-mesenchymal transition.PloS one · 2013Article
- ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous.Human molecular genetics · 2012Article
- Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47.Molecular and cellular biology · 2012Article
- Protein inhibitor of activated STAT, PIASy regulates α-smooth muscle actin expression by interacting with E12 in mesangial cells.PloS one · 2012Article
- N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells.The Journal of biological chemistry · 2011Article
- Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.Journal of cellular biochemistry · 2010Article
- Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways.The Journal of biological chemistry · 2009Article
- Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Calcium regulation of myogenesis by differential calmodulin inhibition of basic helix-loop-helix transcription factors.Molecular biology of the cell · 2008Article
- Function of E-protein dimers expressed in catfish lymphocytes.Molecular immunology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The E2A gene encodes two basic helix-loop-helix proteins designated E12 and E47. Although these proteins are widely expressed, they are required only for the B-lymphocyte lineage where DNA binding is mediated distinctively by E47 homodimers. By studying the properties of deltaE47, an N-terminal truncation of E47, we provide evidence that phosphorylation may contribute to B-cell-specific DNA binding by E47. Two serines N terminal to the deltaE47 basic helix-loop-helix domain were found to be phosphorylated in a variety of cell types but were hypophosphorylated in B cells. Phosphorylating these serines in vitro inhibited DNA binding by deltaE47 homodimers but not by deltaE47-containing heterodimers, such as deltaE47:MyoD. These results argue that hypophosphorylation may be a prerequisite for activity of E47 homodimers in B cells, suggesting the use of an inductive (nonstochastic) step in early B-cell development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.