ArticleMolecular and cellular biology1996
TFIIIC1 acts through a downstream region to stabilize TFIIIC2 binding to RNA polymerase III promoters.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Structural insights into human TFIIIC promoter recognition.Science advances · 2023Article
- A structural perspective of human RNA polymerase III.RNA biology · 2022Article
- Transcription termination by nuclear RNA polymerases.Genes & development · 2009Article
- Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates.Molecular and cellular biology · 2008Article
- A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC.Nucleic acids research · 2006Article
- Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene.Nucleic acids research · 2003Article
- Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.Molecular and cellular biology · 2002Article
- Evidence for a posttranscriptional role of a TFIIICalpha-like protein in Chironomus tentans.Molecular biology of the cell · 2002Article
- Widespread use of TATA elements in the core promoters for RNA polymerases III, II, and I in fission yeast.Molecular and cellular biology · 2001Article
- Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human.Nucleic acids research · 2001Review
- Development of an inducible pol III transcription system essentially requiring a mutated form of the TATA-binding protein.Nucleic acids research · 2001Article
- Nuclear factor 1 (NF1) affects accurate termination and multiple-round transcription by human RNA polymerase III.The EMBO journal · 2000Article
- Survey and summary: transcription by RNA polymerases I and III.Nucleic acids research · 2000Review
- RNA polymerase III transcription: its control by tumor suppressors and its deregulation by transforming agents.Gene expression · 2000Review
- TATA-Binding protein-interacting protein 120, TIP120, stimulates three classes of eukaryotic transcription via a unique mechanism.Molecular and cellular biology · 1999Article
- Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity.Molecular and cellular biology · 1999Article
- Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III.Molecular and cellular biology · 1999Article
- Human TFIIIC relieves chromatin-mediated repression of RNA polymerase III transcription and contains an intrinsic histone acetyltransferase activity.Molecular and cellular biology · 1999Article
- A chimeric subunit of yeast transcription factor IIIC forms a subcomplex with tau95.Molecular and cellular biology · 1998Article
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2 authors.
Funding
Abstract
An in vitro system reconstituted with highly purified RNA polymerase III, TFIIIC2, and TFIIIB has been used to identify two chromatographically distinct human RNA polymerase III transcription factors, TFIIIC1 and TFIIIC1', which are functionally equivalent to the previously defined TFIIIC1 (S. T. Yoshinaga, P. A. Boulanger, and A. J. Berk, Proc. Natl. Acad. Sci. USA 84:3585-3589, 1987). Interactions between TFIIIC2, TFIIIC1 (or TFIIIC1'), and the VA1 and tRNA1(Met) templates have been investigated by DNase I footprint analysis. Homogeneous TFIIIC2 alone shows only a weak footprint over the B-box region of the VA1 and tRNA1(Met) templates, whereas TFIIIC1 (or TFIIIC1') alone shows both a strong interaction over the downstream termination region and a very weak interaction near the A-box region. Importantly, when both factors are present simultaneously, TFIIIC1 (or TFIIIC1') dramatically enhances the level of TFIIIC2 binding and extends the footprint to a region that includes the A box. The downstream termination region is essential for this cooperative interaction between TFIIIC2 and TFIIIC1 (or TFIIIC1') on the VA1 and tRNA1(Met) templates and plays a role in the overall accuracy and efficiency of RNA polymerase III transcription.
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