ArticleMolecular and cellular biology1996
Saccharomyces cerevisiae G1 cyclins differ in their intrinsic functional specificities.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Nucleosome Assembly Protein 1 in Dinoflagellate Cells Without Architectural Nucleosomes.International journal of molecular sciences · 2026Article
- Evidence for novel mechanisms that control cell-cycle entry and cell size.Molecular biology of the cell · 2024Article
- G1-Cyclin2 (Cln2) promotes chromosome hypercondensation in eco1/ctf7 rad61 null cells during hyperthermic stress in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2022Article
- Comprehensive and quantitative analysis of G1 cyclins. A tool for studying the cell cycle.PloS one · 2019Article
- Article
- A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry.Current biology : CB · 2015Article
- A microbial avenue to cell cycle control in the plant superkingdom.The Plant cell · 2014Article
- Molecular basis of the functional distinction between Cln1 and Cln2 cyclins.Cell cycle (Georgetown, Tex.) · 2012Article
- Discovering time-lagged rules from microarray data using gene profile classifiers.BMC bioinformatics · 2011Article
- Rising cyclin-CDK levels order cell cycle events.PloS one · 2011Article
- Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replication.Molecular and cellular biology · 2007Article
- Biochemical characterization of Cdk2-Speedy/Ringo A2.BMC biochemistry · 2005Article
- Article
- Functional distinction between Cln1p and Cln2p cyclins in the control of the Saccharomyces cerevisiae mitotic cycle.Genetics · 2004Article
- Recruitment of Cdc28 by Whi3 restricts nuclear accumulation of the G1 cyclin-Cdk complex to late G1.The EMBO journal · 2004Article
- Article
- ACE2 is required for daughter cell-specific G1 delay in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Glucose regulation of Saccharomyces cerevisiae cell cycle genes.Eukaryotic cell · 2003Article
- The G(1) cyclin Cln3 promotes cell cycle entry via the transcription factor Swi6.Molecular and cellular biology · 2002Article
- Testing a mathematical model of the yeast cell cycle.Molecular biology of the cell · 2002Article
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Authors and funding
3 authors.
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Abstract
The three budding yeast CLN genes appear to be functionally redundant for cell cycle Start: any single CLN gene is sufficient to promote Start, while the cln1 cln2 cln3 triple mutant is Start defective and inviable. Both quantitative and apparently qualitative differences between CLN genes have been reported, but available data do not in general allow distinction between qualitative functional differences as opposed to simply quantitative differences in expression or function. To determine if there are intrinsic qualitative differences between Cln proteins, we compared CLN2, CLN3, and crippled (but still partially active) CLN2 genes in a range of assays that differentiate genetically between CLN2 and CLN3. The results suggest that different potencies of Cln2, Cln3, and Cln2 mutants in functional assays cannot be accounted for by a simple quantitative model for their action, since Cln3 is at least as active as Cln2 and much more active than the Cln2 mutants in driving Swi4/Swi6 cell cycle box (SCB)-regulated transcription and cell cycle initiation in cln1 cln2 cln3 bck2 strains, but Cln3 has little or no activity in other assays in which Cln2 and the Cln2 mutants function. Differences in Cln protein abundance are unlikely to account for these results. Cln3-associated kinase is therefore likely to have an intrinsic in vivo substrate specificity distinct from that of Cln2-associated kinase, despite their functional redundancy. Consistent with the idea that Cln3 may be the primary transcriptional activator of CLN1, CLN2, and other genes, the activation of CLN2 transcription was found to be sensitive to the gene dosage of CLN3 but not to the gene dosage of CLN2.
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