ArticleProceedings of the National Academy of Sciences of the United States of America1996
Deglucosylation of N-linked glycans is an important step in the dissociation of calreticulin-class I-TAP complexes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 81 citations in OpenAlex.
- Essential glycan-dependent interactions optimize MHC class I peptide loading.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A role for UDP-glucose glycoprotein glucosyltransferase in expression and quality control of MHC class I molecules.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Lectin-deficient calreticulin retains full functionality as a chaperone for class I histocompatibility molecules.Molecular biology of the cell · 2008Article
- Ku86 exists as both a full-length and a protease-sensitive natural variant in multiple myeloma cells.Cancer cell international · 2008Article
- Association of beta2-microglobulin with the alpha3 domain of H-2Db heavy chain.Immunogenetics · 2004Article
- Organizational diversity among distinct glycoprotein endoplasmic reticulum-associated degradation programs.Molecular biology of the cell · 2002Article
- Calreticulin recognizes misfolded HLA-A2 heavy chains.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Article
- Activation of human monocyte cell line U937 via cell surface calreticulin.Cell stress & chaperones · 2001Article
- Golgi apparatus immunolocalization of endomannosidase suggests post-endoplasmic reticulum glucose trimming: implications for quality control.Molecular biology of the cell · 2000Article
- Role of N-oligosaccharide endoplasmic reticulum processing reactions in glycoprotein folding and degradation.The Biochemical journal · 2000Review
- Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunity.The Journal of experimental medicine · 1999Article
- ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly.The EMBO journal · 1998Article
- The number and location of glycans on influenza hemagglutinin determine folding and association with calnexin and calreticulin.The Journal of cell biology · 1997Article
- Cloning and functional characterization of a subunit of the transporter associated with antigen processing.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence indicates that newly synthesized major histocompatibility complex (MHC) class I proteins interact with calnexin, a transmembrane endoplasmic reticulum protein specific for certain glycoproteins bearing monoglucosylated glycans. Here, we studied the association of newly synthesized class I proteins with calreticulin, a soluble calnexin-related ER protein, in murine T cells. We found that, unlike calnexin-class I interactions, calreticulin assembly with class I proteins was markedly decreased in the absence of beta 2 microglobulin expression and that calreticulin associated with a subset of class I glycoforms distinct from those assembled with calnexin but similar to those bound to TAP (transporter associated with antigen processing) proteins. Finally, these studies show that deglucosylation of N-linked glycans is important for dissociation of class I proteins from both calreticulin and TAP and that the vast majority of newly synthesized class I proteins associated with calreticulin are simultaneously assembled with TAP. The data demonstrate that calnexin and calreticulin chaperones assemble with distinct MHC class I assembly intermediates in the ER and show that glycan processing is functionally coupled to release of MHC class I proteins from peptide transport molecules.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.