ArticleThe Journal of clinical investigation1996
Association of arthrogryposis multiplex congenita with maternal antibodies inhibiting fetal acetylcholine receptor function.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 159 citations in OpenAlex.
- Identification of novel RIPK4 variants in a Chinese patient with Arthrogryposis Multiplex Congenita (AMC).Italian journal of pediatrics · 2025Article
- Pregnancy in myasthenia gravis: a retrospective analysis of maternal and neonatal outcome from a large tertiary care centre in Germany.Archives of gynecology and obstetrics · 2024Article
- [Myasthenia gravis-Gender aspects and family planning].Der Nervenarzt · 2024Review
- Pathophysiology of Childhood-Onset Myasthenia: Abnormalities of Neuromuscular Junction and Autoimmunity and Its Background.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Review
- The emerging spectrum of fetal acetylcholine receptor antibody-related disorders (FARAD).Brain : a journal of neurology · 2023Article
- Hunting for the elusive target antigen in gestational alloimmune liver disease (GALD).PloS one · 2023Article
- Comparative Analysis of BIOCHIP Mosaic-Based Indirect Immunofluorescence with Enzyme-Linked Immunosorbent Assay for Diagnosing Myasthenia Gravis.Diagnostics (Basel, Switzerland) · 2021Article
- Inhibition of Maternal-to-Fetal Transfer of IgG Antibodies by FcRn Blockade in a Mouse Model of Arthrogryposis Multiplex Congenita.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Maternal-Autoantibody-Related (MAR) Autism: Identifying Neuronal Antigens and Approaching Prospects for Intervention.Journal of clinical medicine · 2020Review
- Myasthenia gravis AChR antibodies inhibit function of rapsyn-clustered AChRs.Journal of neurology, neurosurgery, and psychiatry · 2020Article
- The Structure, Function, and Physiology of the Fetal and Adult Acetylcholine Receptor in Muscle.Frontiers in molecular neuroscience · 2020Review
- Myasthenia Gravis: Autoantibody Specificities and Their Role in MG Management.Frontiers in neurology · 2020Review
- Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics.Frontiers in immunology · 2020Review
- Glycine receptor autoantibodies disrupt inhibitory neurotransmission.Brain : a journal of neurology · 2019Article
- Review
- Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient.Scientific reports · 2017Article
- A mutation of beta-tropomyosin gene in a Chinese family with distal arthrogryposis type I.International journal of clinical and experimental pathology · 2017Article
- Neuronal Surface Autoantibodies in Neuropsychiatric Disorders: Are There Implications for Depression?Frontiers in immunology · 2017Review
- Autoantibodies in Neuropsychiatric Disorders.Antibodies (Basel, Switzerland) · 2016Review
- Arthrogryposis: an update on clinical aspects, etiology, and treatment strategies.Archives of medical science : AMS · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arthrogryposis multiplex congenita (AMC), characterized by multiple joint contractures developing in utero, results from lack of fetal movement. Some cases are genetically determined, but AMC occasionally complicates pregnancy in patients with myasthenia gravis (MG) suggesting involvement of circulating maternal antibodies. We previously demonstrated antibodies that inhibited the function of fetal acetylcholine receptor (AChR) in one healthy woman with an obstetric history of recurrent AMC. Here we study sera from this woman, from one other with a similar history, and from three (one asymptomatic) whose babies had neonatal MG and AMC. All five maternal sera had high titers of antibodies that inhibited alpha-Bungarotoxin (alpha-BuTx) binding to fetal AChR, and their sera markedly inhibited fetal AChR function with little effect on adult AChR function. Moreover, in a further survey, 3 of 20 sera from anti-AChR negative AMC mothers inhibited fetal AChR function significantly at 1:100 dilution. These results demonstrate the role of antibodies to fetal AChR and perhaps other muscle antigens in some cases of AMC. More generally, they suggest that placental transfer of antibodies directed at fetal antigens should be considered as a cause of other recurrent fetal or perinatal disorders.
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