ArticleJournal of clinical microbiology1996
Development of two species-specific fingerprinting probes for broad computer-assisted epidemiological studies of Candida tropicalis.
Article in Journal of clinical microbiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
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- Characterization of Virulence-Related Phenotypes in Candida Species of the CUG Clade.Eukaryotic cell · 2015Article
- Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- CandidaDB: a multi-genome database for Candida species and related Saccharomycotina.Nucleic acids research · 2008Article
- Release of a potent polymorphonuclear leukocyte chemoattractant is regulated by white-opaque switching in Candida albicans.Infection and immunity · 2004Article
- Identification of four distinct genotypes of Candida dubliniensis and detection of microevolution in vitro and in vivo.Journal of clinical microbiology · 2002Article
- Cloning and characterization of a complex DNA fingerprinting probe for Candida parapsilosis.Journal of clinical microbiology · 2001Article
- Candidiasis during pregnancy may result from isogenic commensal strains.Infectious diseases in obstetrics and gynecology · 2001Article
- The ins and outs of DNA fingerprinting the infectious fungi.Clinical microbiology reviews · 2000Review
- Development and characterization of complex DNA fingerprinting probes for the infectious yeast Candida dubliniensis.Journal of clinical microbiology · 1999Article
- Hospital specificity, region specificity, and fluconazole resistance of Candida albicans bloodstream isolates.Journal of clinical microbiology · 1998Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Candida tropicalis has emerged as the second most frequent colonizing Candida species, and it has been documented in nosocomial infections. To develop an effective fingerprinting system for this species, which is amenable to computer-assisted analyses and which provides information on the genetic relatedness of independent isolates, two DNA fragments, Ct3 (18,000 bp) and Ct14 (20,000 bp), were cloned from a genomic library of Sau3AI partial digestion products. Both probes generate complex Southern blot patterns containing 8 to 20 bands, when hybridized to EcoRI- or EcoRI-HaeIII-digested DNA of independent C. tropicalis isolates. The two probes show no cross-hybridization and are both species specific for C. tropicalis. A comparison of the capacity of the two probes to identify the same strain in different isolates, and differentiate unrelated strains, using computer-assisted computation of similarity coefficients and the genesis of dendrograms, suggests that while Ct14 is more effective in grouping independent isolates, Ct3 is more effective in discriminating small differences in the patterns of highly related isolates and is therefore a more effective probe for determining microevolution within a clonal population and substrain shuffling in recurrent infections. Because of their alternative attributes, it is suggested that both probes be used in fingerprinting studies of C. tropicalis.
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Registered trials
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