ArticleAmerican journal of human genetics1996
High mitochondrial sequence diversity in linguistic isolates of the Alps.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Uniparental markers of contemporary Italian population reveals details on its pre-Roman heritage.PloS one · 2012Article
- Functional differences between mitochondrial haplogroup T and haplogroup H in HEK293 cybrid cells.PloS one · 2012Article
- The genetic study of three population microisolates in South Tyrol (MICROS): study design and epidemiological perspectives.BMC medical genetics · 2007Article
- Genetic history of some western Mediterranean human isolates through mtDNA HVR1 polymorphisms.Journal of human genetics · 2006Review
- Etruscan artifacts.American journal of human genetics · 2004Article
- The fingerprint of phantom mutations in mitochondrial DNA data.American journal of human genetics · 2002Article
- mtDna and the islands of the North Atlantic: estimating the proportions of Norse and Gaelic ancestry.American journal of human genetics · 2001Article
- Geographic patterns of mtDNA diversity in Europe.American journal of human genetics · 2000Article
- Why hunter-gatherer populations do not show signs of pleistocene demographic expansions.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Using rare mutations to estimate population divergence times: a maximum likelihood approach.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Trading genes along the silk road: mtDNA sequences and the origin of central Asian populations.American journal of human genetics · 1998Article
- mtDNA analysis reveals a major late Paleolithic population expansion from southwestern to northeastern Europe.American journal of human genetics · 1998Article
- Mitochondrial lineages in Ladin-speaking communities of the eastern Alps.Proceedings. Biological sciences · 1998Article
- Compilation of human mtDNA control region sequences.Nucleic acids research · 1998Article
- DNA variation and language affinities.American journal of human genetics · 1997Article
- An apportionment of human DNA diversity.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
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Authors and funding
7 authors.
Funding
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Abstract
Segment I of the control region of mtDNA (360 bases) was sequenced in seven samples, each of 10 individuals inhabiting villages in the eastern Italian Alps (South Tyrol and Trentino). Three linguistic groups, German, Italian, and Ladin, were represented by two samples each; the seventh sample comes from an isolated group of German origin, the Mocheni, who are linguistically distinct and geographically separated from the bulk of the German speakers. Seventy-four polymorphic sites were identified, defining 63 different haplotypes. Mocheni and Ladin speakers tend to form two clusters in the evolutionary trees inferred from sequences. Analysis of molecular variance shows significant differentiation within samples, among them, and among linguistic groups. Genetic differences between the Ladins and the other groups are not much smaller than between Europeans and some Africans; variation is large within groups, as well, with the exception of only the Mocheni. In the evolutionary trees where the four alpine groups are compared with other European populations, Mocheni and especially Ladins appear as clear outliers. Romansch-speaking Swiss, who are linguistically related to Ladins, are not genetically similar to them, for this segment of DNA. Because the time elapsed since colonization of the Alps (< or = 12,000 years) is short in mutational terms, the only model accounting for the observed relationships between mtDNA variation and linguistic identity seems one in which a population ancestral to Ladin speakers was already differentiated long before the Alps were settled and the current linguistic affiliations were established. For the Mocheni, the results are consistent with a simpler episode of allele loss, from an original genetic pool common to the ancestors of the current German speakers.
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