ArticleAmerican journal of human genetics1996
Individual variation in recombination among human males.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- From molecules to populations: appreciating and estimating recombination rate variation.Nature reviews. Genetics · 2020Review
- Meiotic recombinations within major histocompatibility complex of human embryos.Immunogenetics · 2012Article
- Recombination-associated sequence homogenization of neighboring Alu elements: signature of nonallelic gene conversion.Molecular biology and evolution · 2010Article
- Recombinational landscape of porcine X chromosome and individual variation in female meiotic recombination associated with haplotypes of Chinese pigs.BMC genomics · 2010Article
- Variation in patterns of human meiotic recombination.Genome dynamics · 2009Review
- Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Polymorphic variation in human meiotic recombination.American journal of human genetics · 2007Article
- Article
- High-resolution recombination patterns in a region of human chromosome 21 measured by sperm typing.PLoS genetics · 2006Article
- Whole-genome association analysis to identify markers associated with recombination rates using single-nucleotide polymorphisms and microsatellites.BMC genetics · 2005Article
- Large-scale recombination rate patterns are conserved among human populations.Genome research · 2005Article
- Variation in meiotic recombination frequencies among human males.Human genetics · 2005Article
- Hot and cold spots of recombination in the human genome: the reason we should find them and how this can be achieved.American journal of human genetics · 2003Review
- High-resolution patterns of meiotic recombination across the human major histocompatibility complex.American journal of human genetics · 2002Article
- Article
- Absence of age effect on meiotic recombination between human X and Y chromosomes.American journal of human genetics · 2002Article
- An enhanced linkage map of the sheep genome comprising more than 1000 loci.Genome research · 2001Article
- Article
- Characterization of human crossover interference.American journal of human genetics · 2000Article
- Evidence for heterogeneity in recombination in the human pseudoautosomal region: high resolution analysis by sperm typing and radiation-hybrid mapping.American journal of human genetics · 2000Article
Corrections and comments
- Commented on by
Authors and funding
7 authors.
Funding
Abstract
Studies of recombination between the markers D6S291 and D6S109 in individuals by sperm typing provide direct evidence for significant variation in recombination among humans. A statistically significant difference in the recombination fraction (range 5.1%-11.2%) was detected among five donors. This variation could reflect polymorphisms in genes affecting recombination or in chromosome structure. Ignoring this variability in studies designed to examine the relationship between physical and genetic distances could lead to incorrect inferences. Individual variation in recombination makes it difficult to predict the recombination fraction for an interval in any particular individual. This could be important in certain genetic counseling situations.
Indexed as
Identifiers
8940263PMC1914855What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.