ReviewMolecular neurobiology1996
The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system.
Review in Molecular neurobiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 78 citations in OpenAlex.
- Rosiglitazone and cognitive stability in older individuals with type 2 diabetes and mild cognitive impairment.Diabetes care · 2010 · on this mapTrial
- Epigenetic modification of hypothalamic neuropeptides and metabolic hormone receptors in metabolic health.Frontiers in endocrinology · 2025Review
- Running in mice increases the expression of brain hemoglobin-related genes interacting with the GH/IGF-1 system.Scientific reports · 2024Article
- First Biodistribution Study of [68Ga]Ga-NOTA-Insulin Following Intranasal Administration in Adult Vervet Monkeys.Journal of Alzheimer's disease : JAD · 2024Article
- Hypothalamic neuronal cellular and subcellular abnormalities in experimental obesity.International journal of obesity (2005) · 2019Review
- Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes.Nature communications · 2019Article
- Altered Insulin/Insulin-Like Growth Factor Signaling in a Comorbid Rat model of Ischemia and β-Amyloid Toxicity.Scientific reports · 2018Article
- Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration.Frontiers in neuroscience · 2015Review
- Modulation of hippocampal neural plasticity by glucose-related signaling.Neural plasticity · 2015Review
- Meta-analyses of sevenBiomedical reports · 2014Article
- Hippocampal calcium dysregulation at the nexus of diabetes and brain aging.European journal of pharmacology · 2013Review
- IGF-1-induced enhancement of PRNP expression depends on the negative regulation of transcription factor FOXO3a.PloS one · 2013Article
- Cardiovascular dementia - a different perspective.The open biochemistry journal · 2010Article
- Intrasteric inhibition of ATP binding is not required to prevent unregulated autophosphorylation or signaling by the insulin receptor.Molecular and cellular biology · 2001Article
- Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Several studies support the idea that the polypeptides belonging to the family of insulin and insulin-like growth factors (IGFs) play an important role in brain development and continue to be produced in discrete areas of the adult brain. In numerous neuronal populations within the olfactory bulb, the cerebral and cerebellar cortex, the hippocampus, some diencephalic and brainstem nuclei, the spinal cord and the retina, specific insulin and IGF receptors, as well as crucial components of the intracellular receptor signaling pathway have been demonstrated. Thus, mature neurons are endowed with the cellular machinery to respond to insulin and IGF stimulation. Studies in vitro and in vivo, using normal and transgenic animals, have led to the hypothesis that, in the adult brain, IGF-I not only acts as a trophic factor, but also as a neuromodulator of some higher brain functions, such as long-term potentiation and depression. Furthermore, a trophic effect on certain neuronal populations becomes clearly evident in the ischemic brain or neurodegenerative disorders. Thus, the analysis of the early intracellular signaling pathway for the insulin/IGF receptor family in the brain is providing us with new intriguing findings on the way the mammalian brain is sculpted and operates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.