ArticleBreast cancer research and treatment1996
Human papilloma virus DNA: a factor in the pathogenesis of mammary Paget's disease?
Article in Breast cancer research and treatment, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Human papillomavirus infection and sporadic breast carcinoma risk: a meta-analysis.Breast cancer research and treatment · 2011Pooled it
- Absence of high-risk human papillomavirus in breast cancer tissues from young BRCA1/BRCA2-negative women.BMC women's health · 2026Article
- Presence of Human Papillomavirus DNA in Malignant Neoplasia and Non-Malignant Breast Disease.Current issues in molecular biology · 2022Article
- Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study.BMC cancer · 2017Article
- Article
- Inconclusive role of human papillomavirus infection in breast cancer.Infectious agents and cancer · 2015Article
- Intraductal papilloma of the breast in association with preoncogenic gene of breast cancer.Asian Pacific journal of tropical biomedicine · 2011Article
- Breast cancer and human papillomavirus infection: no evidence of HPV etiology of breast cancer in Indian women.BMC cancer · 2011Article
- Touchdown General Primer (GP5+/GP6+) PCR and optimized sample DNA concentration support the sensitive detection of human papillomavirus.BMC clinical pathology · 2005Article
- Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast.Breast cancer research : BCR · 2005Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The paraffin sections from 20 nipples with Paget's disease (10 central intraductal and 10 invasive ductal carcinomas) were analyzed for human papilloma virus (HPV) DNA of the low- and intermediate/high-risk groups. Polymerase chain reaction (PCR) and dot (slot) blot hybridization were used for the detection of HPV DNA types 6/11/16/18/31/33/35. In addition, we examined the c-erbB-2 oncogene expression in the specimens to differentiate benign cells in the surface epithelium of the nipple and areola from Paget cells. We found that the oncogene expression of the c-erbB-2 displayed a strong signal in the Paget cells. Using PCR and dot (slot) blot hybridization, we could not detect the HPV DNAs that are specific for the low- and intermediate/high risk-groups in the 20 cases of Paget's disease. Our results showed for the first time that this type of virus did not contribute to the pathogenesis of Paget's disease.
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Registered trials
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