ArticlePharmaceutical research1996
Formulation and antitumor activity evaluation of nanocrystalline suspensions of poorly soluble anticancer drugs.
Article in Pharmaceutical research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 231 citations in OpenAlex.
- Improvement of Paclitaxel-Associated Adverse Reactions (ADRs) via the Use of Nano-Based Drug Delivery Systems: A Systematic Review and Network Meta-Analysis.International journal of nanomedicine · 2020Pooled it
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- Use of Flory-Huggins Interaction Parameter and Contact Angle Values to Predict the Suitability of the Drug-Polymer System for the Production and Stability of Nanosuspensions.Pharmaceutical research · 2022Article
- Multiple-mRNA-controlled and heat-driven drug release from gold nanocages in targeted chemo-photothermal therapy for tumors.Chemical science · 2021Article
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- Preparation of parenteral nanocrystal suspensions of etoposide from the excipient free dry state of the drug to enhance in vivo antitumoral properties.Scientific reports · 2020Article
- Transformation of Meloxicam Containing Nanosuspension into Surfactant-Free Solid Compositions to Increase the Product Stability and Drug Bioavailability for Rapid Analgesia.Drug design, development and therapy · 2019Article
- Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability.Pharmaceutics · 2018Review
- Lignin from Micro- to Nanosize: Production Methods.International journal of molecular sciences · 2017Review
- Evaluation of self-assembled HCPT-loaded PEG-b-PLA nanoparticles by comparing with HCPT-loaded PLA nanoparticles.Nanoscale research letters · 2014Article
- Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self-emulsifying systems.ISRN pharmaceutics · 2013Review
- Biomimetic Design of Protein Nanomaterials for Hydrophobic Molecular Transport.Advanced functional materials · 2012Article
- Anti-inflammation effects of Sophora flavescens nanoparticles.Inflammation · 2012Article
- Challenges in development of nanoparticle-based therapeutics.The AAPS journal · 2012Review
- Are high drug loading nanoparticles the next step forward for chemotherapy?Nanomedicine (London, England) · 2012Article
- Designing Paclitaxel drug delivery systems aimed at improved patient outcomes: current status and challenges.ISRN pharmacology · 2012Article
- Drug targeting to infectious diseases by nanoparticles surface functionalized with special biomolecules.Current medicinal chemistry · 2012Review
- Design of dry nanosuspension with highly spontaneous dispersible characteristics to develop solubilized formulation for poorly water-soluble drugs.Pharmaceutical research · 2011Article
- A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer.Investigational new drugs · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDetermine if wet milling technology could be used to formulate water insoluble antitumor agents as stabilized nanocrystalline drug suspensions that retain biological effectiveness following intravenous injection.
methodsThe versatility of the approach is demonstrated by evaluation of four poorly water soluble chemotherapeutic agents that exhibit diverse chemistries and mechanisms of action. The compounds selected were: piposulfan (alkylating agent), etoposide (topoisomerase II inhibitor), camptothecin (topoisomerase I inhibitor) and paclitaxel (antimitotic agent). The agents were wet milled as a 2% w/v solids suspension containing 1% w/v surfactant stabilizer using a low energy ball mill. The size, physical stability and efficacy of the nanocrystalline suspensions were evaluated.
resultsThe data show the feasibility of formulating poorly water soluble anticancer agents as physically stable aqueous nanocrystalline suspensions. The suspensions are physically stable and efficacious following intravenous injection.
conclusionsWet milling technology is a feasible approach for formulating poorly water soluble chemotherapeutic agents that may offer a number of advantages over a more classical approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.