ArticlePharmaceutical research1996
Temperature and pH-sensitive polymers for human calcitonin delivery.
Article in Pharmaceutical research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 130 citations in OpenAlex.
- Effect of nanoparticle loading and magnetic field application on the thermodynamic, optical, and rheological behavior of thermoresponsive polymer solutions.Journal of vinyl & additive technology · 2023Article
- Tuning the thermodynamic, optical, and rheological properties of thermoresponsive polymer solutions via silica nanoparticle shape and concentration.Journal of colloid and interface science · 2023Article
- Cooperativity Principles in Self-Assembled Nanomedicine.Chemical reviews · 2018Review
- Review
- A review of polymers as multifunctional excipients in drug dosage form technology.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2016Review
- Control of gel swelling and phase separation of weakly charged thermoreversible gels by salt addition.Macromolecules · 2007Article
- Polymer molecular weight alters properties of pH-/temperature-sensitive polymeric beads.Pharmaceutical research · 1999Article
- Degradation and aggregation of human calcitonin in vitro.Pharmaceutical research · 1999Article
- Anionic gels as vehicles for electrically-modulated drug delivery. I. Solvent and drug transport phenomena.Pharmaceutical research · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeStimuli-sensitive polymers are suitable candidates for oral peptide drug delivery vehicles since they will prevent gastric degradation in the stomach while providing a controlled release of a peptide drug such as calcitonin later. The purpose of this study was to fabricate polymeric beads from pH/temperature sensitive linear terpolymers (poly(N-isopropylacrylamide-co-butylmethacrylate-co-acrylic acid) and load them with a peptide drug, human calcitonin, which was dissolved in aqueous phase.
methodsThe polymeric beads were formed by solubilizing a cold, aqueous solution of temperature sensitive polymer with human calcitonin. This solution was added dropwise into an oil bath kept at a temperature above the LCST of a polymer, precipitating polymer and entrapping the peptide. The quantity and the physical state of the peptide were analyzed by reverse-phase HPLC, CD and FTIR and its biological activity after loading was determined in vivo.
resultsThe loading efficiency and stability of human calcitonin into the polymeric beads was studied as a function of pH and ionic strength of the loading buffer and temperature of the oil bath. Final optimal loading conditions were 20 mM glycine/HCl buffer, pH 3.0 containing 0.15 M NaCl as a dissolution medium and 23 degrees C as the oil bath temperature. Loading and release of human calcitonin were also studied as a function of acrylic acid content in the terpolymers. As the acrylic acid content increased from 0 to 10 mol %, the loading efficiency and stability of calcitonin improved significantly. The same trend was observed for the quantity of released calcitonin. In vivo biological activity of the released hormone was preserved.
conclusionsThe results showed that the beads made of the polymers with high content of acrylic acid (most hydrophilic) provided better loading, stability and release of human calcitonin. The designed beads represent a new potential system for oral delivery of calcitonin and other peptides.
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