ArticleNucleic acids research1996
Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 74 citations in OpenAlex.
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- FAM72, Glioblastoma Multiforme (GBM) and Beyond.Cancers · 2021Review
- Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory complex-I activity via Bcl-2 family proteins.Oncotarget · 2014Article
- MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx.Antioxidants & redox signaling · 2014Review
- E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression.Genes & development · 2012Article
- Oxidative Stress Induced by MnSOD-p53 Interaction: Pro- or Anti-Tumorigenic?Journal of signal transduction · 2012Article
- p53 acts as a co-repressor to regulate keratin 14 expression during epidermal cell differentiation.PloS one · 2012Article
- p53 regulates Ki-67 promoter activity through p53- and Sp1-dependent manner in HeLa cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- Forced expression of heat shock protein 27 (Hsp27) reverses P-glycoprotein (ABCB1)-mediated drug efflux and MDR1 gene expression in Adriamycin-resistant human breast cancer cells.The Journal of biological chemistry · 2011Article
- The biology of lysine acetylation integrates transcriptional programming and metabolism.Nutrition & metabolism · 2011Article
- One function--multiple mechanisms: the manifold activities of p53 as a transcriptional repressor.Journal of biomedicine & biotechnology · 2011Review
- Mechanisms of p53-mediated repression of the human polycystic kidney disease-1 promoter.Biochimica et biophysica acta · 2010Article
- Nuclear factor kappaB- and specificity protein 1-dependent p53-mediated bi-directional regulation of the human manganese superoxide dismutase gene.The Journal of biological chemistry · 2010Article
- Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites.Nucleic acids research · 2008Article
- Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4alpha (HNF4alpha) gene.The Biochemical journal · 2006Article
- Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression.The Journal of biological chemistry · 2006Article
- SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing.Neoplasia (New York, N.Y.) · 2005Article
- Over-expression of TATA binding protein (TBP) and p53 and autoantibodies to these antigens are features of systemic sclerosis, systemic lupus erythematosus and overlap syndromes.Clinical and experimental immunology · 2004Article
- p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB.The EMBO journal · 2003Article
- Several regions of p53 are involved in repression of RNA polymerase III transcription.Oncogene · 2002Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In addition to serving a role as a DNA binding-dependent transcriptional activator, p53 has been reported to repress a variety of promoters that lack p53 binding sites. Data from recent studies have suggested that this activity is mediated via an interaction between p53 and the TATA box binding protein (TBP). To investigate the functional relevance of this interaction in vivo, we have performed transient transfection assays in Drosophila Schneider cells. Wild-type p53 was found to repress expression from TATA box- but not initiator (Inr)-containing promoters activated by GAL4-VP16, GAL4-ftzQ or Sp1. A mutant p53(His175), defective in DNA binding and transcriptional activation, also inhibited TATA-dependent transcription activated by Sp1. However, p53 was unable to repress a basal TATA promoter stimulated by overexpression of TBP. Furthermore, overexpression of TBP failed to rescue the p53-mediated repression of activated transcription and a p53 mutant with its N-terminal TBP interaction domain intact, but defective in transcriptional activation and binding to TBP-associated factors (TAFs), was similarly defective in transcriptional repression. These data suggest that a p53-TBP interaction is not sufficient for transcriptional repression by p53 and that repression involves an interaction between p53 and other factors, such as TAFs, that are required for activated but not basal transcription. We suggest that p53-mediated repression results from squelching of a factor limiting for activated transcription from TATA- but not Inr-containing promoters.
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