Evidence map›Paper›PMID 8930843›Full record

ArticleThe Journal of physiology1996

Non-NMDA receptors transmit cardiopulmonary C fibre input in nucleus tractus solitarii in rats.

C G Wilson, Z Zhang, A C Bonham

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 67 citations in OpenAlex.

  1. Nitric oxide synthase activation in nTS is essential to NMDA receptor dependent encoding of the cough reflex.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. An essential component to brainstem cough gating identified in anesthetized guinea pigs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010
    Article
  9. Article
  10. Central regulation of the cough reflex: therapeutic implications.Pulmonary pharmacology & therapeutics · 2009
    Review
  11. Sensory nerves and airway irritability.Handbook of experimental pharmacology · 2009
    Review
  12. Article
  13. Central pathways of pulmonary and lower airway vagal afferents.Journal of applied physiology (Bethesda, Md. : 1985) · 2006
    Review
  14. Article
  15. Review
  16. Article
  17. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

C G WilsonUniversity of California, Division of Cardiovascular Medicine, Davis 95616, USA.
Z Zhang
A C Bonham
University of California, Davis · US

Funding

REGULATION OF CARDIAC AFFERENTS BY OXYGEN RADICALSP01HL052165 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI BONHAM, ANN C. · 1995 to 1999
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CNS PROCESSING OF BRONCHOPULMONARY FIBER AFFERENT INPUTR29HL048584 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI BONHAM, ANN C. · 1992 to 1996
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NHLBI NIH HHS HL48584NHLBI NIH HHS HL52165
6 · The paper itself

Abstract

1. We sought first to determine whether neurones in caudomedial aspects of commissural nucleus tractus solitarii (NTS) received input from cardiopulmonary C fibre endings supplied by the pulmonary versus systemic circulation. We then examined the role of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in transmitting cardiopulmonary C fibre input to such NTS neurones. 2. Extracellular NTS unit activity, phrenic nerve activity and arterial blood pressure were recorded in urethane-anaesthetized rats. Unit responses to right atrial and left ventricular phenylbiguanide injections were compared in rats with arterial baroreceptors, carotid chemo-receptors and subdiaphragmatic vagal inputs eliminated. Right atrial phenylbiguanide injections produced greater peak responses (27 +/- 11 impulses s-1) than did left ventricular injections (11 +/- 3 impulses s-1) (n = 9). 3. The non-NMDA receptor agonist quisqualic acid (QUIS) and NMDA were ionophoresed onto NTS neurones that were synaptically activated by right atrial phenylbiguanide injection. Responses were compared before and during ionophoresis of the non-NMDA receptor antagonist 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(f)quinoxaline (NBQX), the NMDA receptor antagonist DL-2-amino-5-phosphovaleric acid (AP5), or the broad spectrum antagonist kynurenic acid (KYN). 4. NBQX, which blocked QUIS-but spared NMDA-evoked responses, significantly attenuated synaptic activation by 65% (n = 9). AP5, which blocked NMDA- but spared QUIS-evoked responses, did not significantly diminish synaptic activation (11%; n = 7). KYN, which blocked QUIS- and NMDA-evoked responses, decreased synaptic activation by 70% (n = 9). 5. The results suggest that input from cardiopulmonary C fibre endings, primarily supplied by the pulmonary circulation, is transmitted to this commissural NTS region largely via non-NMDA receptors.

Indexed as

Heart Conduction System2-Amino-5-phosphonovalerateAfferent PathwaysAnimalsBiguanidesBrain MappingChemoreceptor CellsExcitatory Amino Acid AntagonistsHeartHeart AtriaHeart VentriclesKynurenic AcidLungMaleNerve FibersNeurons2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline2-Amino-5-phosphonovalerateBiguanidesExcitatory Amino Acid AntagonistsKynurenic AcidN-Methylaspartatephenyl biguanideQuinoxalinesQuisqualic AcidSerotonin Receptor Agonists

Identifiers

PMID8930843
PMCPMC1160863
OpenAlexW1975986174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.