ArticleThe Journal of physiology1996
Acidosis of rat dorsal vagal neurons in situ during spontaneous and evoked activity.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
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- Parkinson disease and the gut: new insights into pathogenesis and clinical relevance.Nature reviews. Gastroenterology & hepatology · 2020Review
- Neurophysiology of the brain stem in Parkinson's disease.Journal of neurophysiology · 2019Review
- Acid-Sensing Ion Channels Activated by Evoked Released Protons Modulate Synaptic Transmission at the Mouse Calyx of Held Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically Encoded pH Sensors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Fluorescent ratiometric pH indicator SypHer2: Applications in neuroscience and regenerative biology.Biochimica et biophysica acta · 2015Article
- Ion dynamics during seizures.Frontiers in cellular neuroscience · 2015Review
- Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface.The Journal of biological chemistry · 2014Article
- Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Genetically encoded proton sensors reveal activity-dependent pH changes in neurons.Frontiers in molecular neuroscience · 2012Article
- Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity.The Journal of biological chemistry · 2011Article
- Article
- High-performance genetically targetable optical neural silencing by light-driven proton pumps.Nature · 2010Article
- Negative shift in the glycine reversal potential mediated by a Ca2+- and pH-dependent mechanism in interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Effects of leucine-enkephalin on potassium currents in neurons in the rat respiratory center in vitro.Neuroscience and behavioral physiology · 2007Article
- P2Y1 receptor modulation of the pre-Bötzinger complex inspiratory rhythm generating network in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Somatic vs. dendritic responses to hypercapnia in chemosensitive locus coeruleus neurons from neonatal rats.American journal of physiology. Cell physiology · 2005Article
- TASK-like K+ channels mediate effects of 5-HT and extracellular pH in rat dorsal vagal neurones in vitro.The Journal of physiology · 2005Article
- Response of membrane potential and intracellular pH to hypercapnia in neurons and astrocytes from rat retrotrapezoid nucleus.American journal of physiology. Regulatory, integrative and comparative physiology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Rat brainstem slices were taken for simultaneous measurements of intracellular pH (pHi) and membrane currents or potentials in dorsal vagal neurons, dialysed with the pH-sensitive dye BCECF. 2. Intrinsic intracellular buffering power was 18 mM per pH unit, as determined by exposure to trimethylamine in CO2/HCO3(-)-free, Hepes-buffered saline. 3. Tonic spike activity led to a stable fall in pHi of 0.05-0.2 pH units from a baseline of 7.19 in current-clamp mode, whereas depolarization from -60 to 0 mV for 1 min in voltage-clamp mode produced an intracellular acidification of 0.3 pH units. The depolarization-evoked fall in pHi was suppressed by 1 mM Ni2+ or 0.2 mM Cd2+, but not by 0.5 microM TTX or CO2/HCO3(-)-free saline. 4. Kainate (100 microM) led to an an inward current of -620 pA and a threefold increase in membrane conductance, accompanied by a fall in pHi of 0.33 pH units. 5. GABA (1 mM) evoked a bicuculline-blockable conductance increase and fall in pHi of up to 0.5 pH units. The GABA-induced pHi decrease, but not the conductance increase, was suppressed in Hepes solution. 6. Neither tonic spike activity, nor resting current or conductance were markedly changed upon Hepes-induced intracellular alkalinizations of up to 0.35 pH units, or by an anoxia-induced fall in pHi of a maximum of 0.36 pH units. 7. The data show that neuronal activity produces profound changes in pHi. It appears that spontaneous spike discharge of dorsal vagal neurons is rather tolerant of major perturbations in pHi.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.