Trial reportEnvironmental health perspectives1996
Exposure to pesticides and cryptorchidism: geographical evidence of a possible association.
Trial report in Environmental health perspectives, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Testicular dysgenesis syndrome and the estrogen hypothesis: a quantitative meta-analysis.Environmental health perspectives · 2008Pooled it
- Non-cancer health effects of pesticides: systematic review and implications for family doctors.Canadian family physician Medecin de famille canadien · 2007Pooled it
- Pesticide Exposures during Pregnancy and Health Outcomes in Latin America and the Caribbean: A Scoping Review of Human Observational Studies.Journal of health & pollution · 2024Review
- Endocrine-Disrupting Chemicals, Hypothalamic Inflammation and Reproductive Outcomes: A Review of the Literature.International journal of molecular sciences · 2024Review
- Review
- Frequency of urinary pesticides in children: a scoping review.Frontiers in public health · 2023Article
- Article
- Association of pesticide exposure with human congenital abnormalities.Toxicology and applied pharmacology · 2018Review
- Giant toads (Rhinella marina) living in agricultural areas have altered spermatogenesis.The Science of the total environment · 2017Article
- Risk factors for cryptorchidism.Nature reviews. Urology · 2017Review
- Increased prevalence of some birth defects in Korea, 2009-2010.BMC pregnancy and childbirth · 2016Article
- Female farmworkers' perceptions of pesticide exposure and pregnancy health.Journal of immigrant and minority health · 2012Article
- The risk of cryptorchidism among sons of women working in horticulture in Denmark: a cohort study.Environmental health : a global access science source · 2011Article
- [Carcinoma in situ of the testis: predisposition, evolution and early detection].Der Pathologe · 2011Review
- Trends in the incidence of cryptorchidism and hypospadias of registry-based data in Korea: a comparison between industrialized areas of petrochemical estates and a non-industrialized area.Asian journal of andrology · 2011Article
- Endocrine disrupting chemicals: Multiple effects on testicular signaling and spermatogenesis.Spermatogenesis · 2011Article
- Endocrine-disrupting chemicals: an Endocrine Society scientific statement.Endocrine reviews · 2009Review
- [Molecular pathology of testicular germ cell tumors: an update].Der Pathologe · 2008Article
- Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy.Environmental health perspectives · 2008Article
- Human exposure to endocrine-disrupting chemicals and prenatal risk factors for cryptorchidism and hypospadias: a nested case-control study.Environmental health perspectives · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthetic hormone-disrupting chemicals may play a role in the increased frequency of cryptorchidism observed in some studies. We used a spatial ecological design to search for variations in orchidopexy rates in the province of Granada in Spain and to search for relationships between these differences and geographical variations in exposure to pesticides. Orchidopexy rates were estimated for the period from 1980 to 1991 in all municipalities and health care districts served by the University of Granada Hospital. A random sample of males of the same age (1-16 years) admitted for any reason during the same period was used to estimate inpatient control rates. Each municipality was assigned to one of four levels of pesticide use. We used Poisson homogeneity tests to detect significant differences in rates of orchidopexy between districts and between levels of pesticide use. Poisson and logistic regression models were also used to estimate the strength of association between orchidopexy and level of pesticide use. Orchidopexy rates tended to be higher in districts near the Mediterranean coast where intensive farming is widespread. The city of Granada, where the reference hospital is located, also had higher figures both for orchidopexy and inpatient control rates. Regression models showed that the strength of association between orchidopexy and level of pesticide use tended to increase with higher levels of use, with the exception of level 0 (mainly in the city of Granada). Our results are compatible with a hypothetical association between exposure to hormone-disruptive chemicals and the induction of cryptorchidism. Several methodological limitations in the design make it necessary to evaluate the results with caution.
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