ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Translational machinery in dendrites of hippocampal neurons in culture.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 206 citations in OpenAlex.
- ER discontinuities are common inbioRxiv : the preprint server for biology · 2026Article
- Autoimmune RNA dysregulation and seizures: therapeutic prospects in neuropsychiatric lupus.Life science alliance · 2022Article
- A Ribosomal Perspective on Neuronal Local Protein Synthesis.Frontiers in molecular neuroscience · 2022Review
- The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Measuring mRNA translation in neuronal processes and somata by tRNA-FRET.Nucleic acids research · 2020Article
- Review
- Homeostatic Roles of the Proteostasis Network in Dendrites.Frontiers in cellular neuroscience · 2020Review
- The Role of RNA Binding Proteins for Local mRNA Translation: Implications in Neurological Disorders.Frontiers in molecular biosciences · 2019Review
- New approaches for solving old problems in neuronal protein trafficking.Molecular and cellular neurosciences · 2018Review
- G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway?Frontiers in endocrinology · 2018Review
- Long-term memory consolidation: The role of RNA-binding proteins with prion-like domains.RNA biology · 2017Review
- Is Arc mRNA Unique: A Search for mRNAs That Localize to the Distal Dendrites of Dentate Gyrus Granule Cells Following Neural Activity.Frontiers in molecular neuroscience · 2017Article
- BC1 RNA motifs required for dendritic transport in vivo.Scientific reports · 2016Article
- Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Potential natural products for Alzheimer's disease: targeted search using the internal ribosome entry site of tau and amyloid-β precursor protein.International journal of molecular sciences · 2015Article
- Identification of Srp9 as a febrile seizure susceptibility gene.Annals of clinical and translational neurology · 2014Article
- Meet the players: local translation at the synapse.Frontiers in molecular neuroscience · 2014Article
- Long-term effects of cocaine experience on neuroplasticity in the nucleus accumbens core of addiction-prone rats.Neuroscience · 2013Article
- Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated presynaptic and postsynaptic transcription and translation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Dendritic protein synthesis in the normal and diseased brain.Neuroscience · 2013Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
In neurons, several mRNAs are selectively delivered to dendritic domains where they are presumably translated by local protein synthetic machinery. Although electron microscopy has identified polyribosomes in dendrites, in particular in postsynaptic dendritic compartments, the functional composition of the local protein synthetic apparatus and the scope of its translational capacity have not been analyzed. To ascertain the translational competence of dendrites, we have probed hippocampal neurons in primary culture for various integral and associated factors of the translational apparatus. We report here that dendrites of such neurons are equipped with a spectrum of translational machinery components, including ribosomes, tRNAs, initiation and elongation factors, and elements of the cotranslational signal recognition mechanism. These components are differentially and nonuniformly distributed in dendritic arbors. Their dendritic location illustrates the soma-independent potential of dendrites to synthesize selected proteins in local domains.
Indexed as
Identifiers
8929426PMC6578937W1501571963What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.