ArticlePflugers Archiv : European journal of physiology1996
The amiloride inhibitable Na+ conductance of rat colonic crypt cells is suppressed by forskolin.
Article in Pflugers Archiv : European journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Effects of chronic hypoxia on electrogenic transport and transport-related oxygen consumption in rat distal colon.Digestive diseases and sciences · 2008Article
- Lung infections associated with cystic fibrosis.Clinical microbiology reviews · 2002Review
- Article
- Basolateral K+ channel involvement in forskolin-activated chloride secretion in human colon.The Journal of physiology · 1999Article
- Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways.The Journal of clinical investigation · 1998Article
- Cl- transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co-expressing CFTR and ENaC.The Journal of physiology · 1998Article
- Regulation of epithelial ion channels by the cystic fibrosis transmembrane conductance regulator.Journal of molecular medicine (Berlin, Germany) · 1996Review
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Previously we have shown that mid crypt cells of corticoid treated rats possess an amiloride inhibitable Na+ conductance (NAC) and show an increased Cl- conductance when stimulated by prostaglandin or the second messenger cAMP. The NAC is supposed to determine the magnitude of NaCl absorption. The Cl- conductance defines the magnitude of NaCl secretion. In the present whole cell (WC) patch clamp study we have examined whether the amiloride (3 "mu"mol/l) inhibitable NAC is downregulated when the Cl- conductance is increased by forskolin (5 "mu"mol/l, n=20) or the phosphodiesterase inhibitor IBMX (1 mmol/l, n=5). Under control conditions the amiloride inhibitable NAC was 2.7+/-0.4 nS. Forskolin depolarized the voltage from -58+/-2.0 to -48+/-1.9 mV and enhanced the WC conductance by 3.25+/-0.6 nS in these cells. The amiloride inhibitable NAC was reduced to 0.38+/-0.2 nS. These data confirm that forskolin enhances the Cl- conductance in these cells and they show for the first time that the Na+ conductance is reduced simultaneously. Thus the cells are able to change the direction of NaCl transport from absorption to secretion.
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