ArticleInfection and immunity1996
Apoptosis of monocytes and prolonged survival of granulocytes as a result of phagocytosis of bacteria.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 117 citations in OpenAlex.
- Development of an intestinal mucosaJournal of virology · 2024Article
- Prevention of aspirin-mediated secondary toxicity by combined treatment of carotenoids in macrophages.3 Biotech · 2023Article
- SARS-CoV-2 infection impairs NK cell functionsFrontiers in immunology · 2023Article
- The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infection.Frontiers in immunology · 2022Article
- Hydrogel nanoparticle degradation influences the activation and survival of primary macrophages.Journal of materials chemistry. B · 2021Article
- Transition Metal Containing Particulate Matter Promotes Th1 and Th17 Inflammatory Response by Monocyte Activation in Organic and Inorganic Compounds Dependent Manner.International journal of environmental research and public health · 2020Article
- Sera of patients with axial spondyloarthritis (axSpA) enhance osteoclastogenic potential of monocytes isolated from healthy individuals.BMC musculoskeletal disorders · 2018Article
- Human monocyte subsets exhibit divergent angiotensin I-converting activity.Clinical and experimental immunology · 2015Article
- Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide.PLoS pathogens · 2015Article
- miR-15a/16 regulates macrophage phagocytosis after bacterial infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Validation of a medium-throughput method for evaluation of intracellular growth of Mycobacterium tuberculosis.Clinical and vaccine immunology : CVI · 2010Article
- Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function.Blood · 2009Article
- Article
- A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytes.Journal of innate immunity · 2009Article
- Direct effect of human immunodeficiency virus protease inhibitors on neutrophil function and apoptosis via calpain inhibition.Clinical and vaccine immunology : CVI · 2007Article
- A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils.Infection and immunity · 2007Article
- Regulation of Apoptosis by Gram-Positive Bacteria: Mechanistic Diversity and Consequences for Immunity.Current immunology reviews · 2006Article
- The Toll-like receptor 4 (Asp299Gly) polymorphism is a risk factor for Gram-negative and haematogenous osteomyelitis.Clinical and experimental immunology · 2006Article
- In vivo interleukin-6 protects neutrophils from apoptosis in osteomyelitis.Infection and immunity · 2004Article
- Caspase-8 activation precedes alterations of mitochondrial membrane potential during monocyte apoptosis induced by phagocytosis and killing of Staphylococcus aureus.Infection and immunity · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monocytes and granulocytes were incubated with suspensions of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, or Salmonella enteritidis and, after being washed free of bacteria, cultured for up to 48 h. Every few hours, samples of cultured cells were taken for DNA isolation. Monocytes which phagocytosed bacteria showed features of apoptotic cells, as determined by light microscopy and DNA fragmentation detected by gel electrophoresis. The phenomenon was observed 2 to 4 h after phagocytosis, in contrast, control monocytes did not show signs of apoptosis until 48 h of culture. Intact control granulocytes spontaneously became apoptotic after 12 h of culture. In contrast, degradation of DNA in cells exposed to bacteria was delayed by 12 to 24 h. In conclusion, our observation suggests that granulocytes and monocytes react differently to phagocytosis of bacteria.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.