ArticleInfection and immunity1996
Production of interleukin-10 and transforming growth factor beta by peripheral blood mononuclear cells in Q fever endocarditis.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 79 citations in OpenAlex.
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- Hacking the host: exploitation of macrophage polarization by intracellular bacterial pathogens.Pathogens and disease · 2020Review
- Comparative virulence of diverse Coxiella burnetii strains.Virulence · 2019Article
- Inflammatory biomarkers in infective endocarditis: machine learning to predict mortality.Clinical and experimental immunology · 2019Article
- Viable Coxiella burnetii Induces Differential Cytokine Responses in Chronic Q Fever Patients Compared to Heat-Killed Coxiella burnetii.Infection and immunity · 2018Article
- Coxiella burnetii Induces Inflammatory Interferon-Like Signature in Plasmacytoid Dendritic Cells: A New Feature of Immune Response in Q Fever.Frontiers in cellular and infection microbiology · 2016Article
- Dysregulation of serum gamma interferon levels in vascular chronic Q Fever patients provides insights into disease pathogenesis.Clinical and vaccine immunology : CVI · 2015Article
- Early cytokine and antibody responses against Coxiella burnetii in aerosol infection of BALB/c mice.Diagnostic microbiology and infectious disease · 2015Article
- Cytokine Signature in Infective Endocarditis.PloS one · 2015Article
- The effect of C. burnetii infection on the cytokine response of PBMCs from pregnant goats.PloS one · 2014Article
- Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii.Nature reviews. Microbiology · 2013Review
- Article
- Animal models of Q fever (Coxiella burnetii).Comparative medicine · 2013Review
- Coxiella burnetii isolates cause genogroup-specific virulence in mouse and guinea pig models of acute Q fever.Infection and immunity · 2009Article
- Adaptive immunity to the obligate intracellular pathogen Coxiella burnetii.Immunologic research · 2009Review
- Persistent Coxiella burnetii infection in mice overexpressing IL-10: an efficient model for chronic Q fever pathogenesis.PLoS pathogens · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of Q fever endocarditis is characterized by the suppression of antigen-specific cell-mediated immune responses. We investigated the production of interleukin-10 (IL-10) and transforming growth factor beta (TGF-beta), known to interfere with the development of protective cell immunity. IL-10 was markedly released by unstimulated peripheral blood mononuclear cells (PBMC) from patients with Q fever endocarditis. This release resulted from the upregulation of IL-10 gene transcription. Similarly, the release of TGF-beta1 and TGF-beta2 was significantly higher in patient PBMC than in control cells, but the expression of their respective mRNA was not enhanced in patient cells. In contrast, lipopolysaccharide-stimulated transcription and release of IL-10 and TGF-beta were similar in patients and controls. The release of IL-10 by PBMC but not that of TGF-beta was correlated with the clinical status of the patients. First, IL-10 production was correlated with specific antibody levels. Second, IL-10 release remained elevated in patients prone to relapse. Taken together, our results suggest that the release of IL-10 and TGF-beta is upregulated in Q fever endocarditis. IL-10 might be considered as a marker of disease relapses and might be instrumental in monitoring the efficiency of the treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.