ArticleInfection and immunity1996
Attachment of Toxoplasma gondii to host cells is host cell cycle dependent.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Human Retinal Organoid Model of Ocular Toxoplasmosis.Pathogens (Basel, Switzerland) · 2025Article
- CRISPR-based functional profiling of the Toxoplasma gondii genome during acute murine infection.Nature microbiology · 2024Article
- Phosphoproteome ofThe American journal of tropical medicine and hygiene · 2017Article
- Exosomes Secreted by Toxoplasma gondii-Infected L6 Cells: Their Effects on Host Cell Proliferation and Cell Cycle Changes.The Korean journal of parasitology · 2016Article
- Article
- Toxoplasma gondii Rhoptry Protein ROP16 Mediates Partially SH-SY5Y Cells Apoptosis and Cell Cycle Arrest by Directing Ser15/37 Phosphorylation of p53.International journal of biological sciences · 2015Article
- Toxoplasma gondii development of its replicative niche: in its host cell and beyond.Eukaryotic cell · 2014Review
- Primary intraocular (retinal) lymphoma after ocular toxoplasmosis.Retinal cases & brief reports · 2010Article
- Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2009Review
- Induction of mitotic S-phase of host and neighboring cells by Toxoplasma gondii enhances parasite invasion.Molecular and biochemical parasitology · 2009Article
- Infection with Toxoplasma gondii results in dysregulation of the host cell cycle.Cellular microbiology · 2008Article
- Cell surface heparan sulfate promotes replication of Toxoplasma gondii.Infection and immunity · 2005Article
- Toxoplasma gondii: changes of transepithelial ion transport in infected HT29/B6 cell monolayers.Parasitology research · 2004Article
- Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex.The EMBO journal · 2003Article
- Characterization of an intestinal epithelial cell receptor recognized by the Cryptosporidium parvum sporozoite ligand CSL.Infection and immunity · 2001Article
- Attachment of Toxoplasma gondii to a specific membrane fraction of CHO cells.Infection and immunity · 2000Article
- Lytic cycle of Toxoplasma gondii.Microbiology and molecular biology reviews : MMBR · 2000Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The initial attachment of Toxoplasma tachyzoites to target host cells is an important event in the life cycle of the parasite and hence critical in the pathogenesis of this infection. The efficiency of Toxoplasma attachment to synchronized populations of Chinese hamster ovary cells and bovine kidney cells was investigated by using a glutaraldehyde-fixed host cell assay system. For both cell lines, parasite attachment increased as the synchronized host cells proceeded from the G1 phase to the mid-S phase and then decreased as the cells entered the G2-M boundary. Postulating that these differences in attachment reflect the upregulation of a specific receptor, polyclonal antibodies were generated against whole MDBK antigen at 0 and 4 h into the S phase. Both antisera were shown to inhibit parasite attachment to both synchronous and asynchronous host cell populations. However, the attachment blockade observed with the 4-h antiserum was significantly greater than that with the 0-h antiserum, completely abolishing the cell cycle-dependent increase in attachment found in control samples. These findings suggest that Toxoplasma tachyzoites bind specifically to a host cell receptor which is upregulated in the mid-S phase of the cell cycle.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.