Evidence map›Paper›PMID 8926050›Full record

ArticleInflammation1996

Effect of the PAF-receptor antagonist SM-12502 on human platelets.

M Köller, R A Hilger, W König

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Inflammation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

M KöllerLehrstuhl für Medizinische Mikrobiologie und Immunologie, Ruhr-Universität Bochum, Germany.
R A Hilger
W König
Ruhr University Bochum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either the Ca ionophore A23187, with human thrombin, or with an activator of heterotrimeric G-proteins, sodium fluoride (NaF, in the presence of Al3+). Preincubation of platelets with the PAF receptor antagonist led to an inhibition of 12-lipoxygenase derived 12(S)-HETE and cyclooxygenase derived 12(S)-HHT. Pretreatment of platelets with the PAF receptor antagonist SM-12502 prior to activation with the Ca ionophore A23187 or PAF also inhibited platelet aggregation. Our data clearly indicate an inhibitory effect of the new PAF receptor antagonist SM-12502 on the formation of platelet derived inflammatory mediators of the lipoxygenase pathway as well as of the cyclooxygenase pathway, and furtherone, treatment with the PAF receptor antagonist diminished platelet aggregation after subsequent specific and unspecific activation.

Indexed as

Receptors, Cell SurfaceReceptors, G-Protein-Coupled12-Hydroxy-5,8,10,14-eicosatetraenoic AcidAluminumArachidonate 12-LipoxygenaseCalcimycinCalciumFatty Acids, UnsaturatedGene Expression RegulationGTP-Binding ProteinsHumansIonophoresPlatelet Activating FactorPlatelet ActivationPlatelet AggregationPlatelet Aggregation Inhibitors12-Hydroxy-5,8,10,14-eicosatetraenoic Acid12-hydroxy-5,8,10-heptadecatrienoic acid3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-oneAluminumArachidonate 12-LipoxygenaseCalcimycinCalciumFatty Acids, UnsaturatedGTP-Binding ProteinsIonophoresPlatelet Activating Factorplatelet activating factor receptorPlatelet Aggregation InhibitorsPlatelet Membrane GlycoproteinsProstaglandin-Endoperoxide SynthasesReceptors, Cell SurfaceReceptors, G-Protein-CoupledSodium FluorideThiazolesThiazolidinesThrombin

Identifiers

PMID8926050
OpenAlexW1994391835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.