ArticleInflammation1996
Candida albicans induces the release of inflammatory mediators from human peripheral blood monocytes.
Article in Inflammation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- Candida spp. co-infection in COVID-19 patients with severe pneumonia: Prevalence study and associated risk factors.Respiratory medicine · 2021Observational
- Role for IL-1 Family Cytokines in Fungal Infections.Frontiers in microbiology · 2021Review
- Antimicrobial activity and acetylcholinestrase inhibition of novel synthesized pyrimidine derivatives versusToxicology reports · 2019Article
- Modulation of Cyp450, ALS1 and COX-2 signaling pathways induced bySaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- Evaluation of APR1 Gene Expression in Candida albicans Strains Isolated From Patients With Multiple Sclerosis.Jundishapur journal of microbiology · 2016Article
- Inhibition of monocytic interleukin-12 production by Candida albicans via selective activation of ERK mitogen-activated protein kinase.Infection and immunity · 2004Article
- Deregulated production of protective cytokines in response to Candida albicans infection in patients with chronic mucocutaneous candidiasis.Infection and immunity · 2003Article
- Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes.Clinical microbiology reviews · 2003Review
- Immunomodulatory and protective effects of moxifloxacin against Candida albicans-induced bronchopneumonia in mice injected with cyclophosphamide.Antimicrobial agents and chemotherapy · 2002Article
- Role of alveolar macrophages in Candida-induced acute lung injury.Clinical and diagnostic laboratory immunology · 2001Article
- Effects of cytokines and fluconazole on the activity of human monocytes against Candida albicans.Antimicrobial agents and chemotherapy · 2001Article
- Candida albicans and Candida krusei differentially induce human blood mononuclear cell interleukin-12 and gamma interferon production.Infection and immunity · 2000Article
- Macrophages in resistance to candidiasis.Microbiology and molecular biology reviews : MMBR · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Candida albicans (C. albicans) is a major nosocomial pathogen. We examined arachidonic acid (AA) and cytokine production by monocytes stimulated with C. albicans. [14C]-AA labeled monocytes released 8.9 +/- 2.3% of the incorporated AA following stimulation with live C. albicans (C. albicans: monocyte of 16:1) (P = 0.0002). Prior studies indicate that soluble alpha-mannans and beta-glucans antagonize mannose and beta-glucan receptors, respectively. Preincubation of monocytes with alpha-mannan (100 micrograms/ml) caused 45.8 +/- 5.7% inhibition of [14C]-AA release, whereas beta-glucan (100 micrograms/ml) yielded 43.7 +/- 6.0% inhibition (P < 0.05 for each compared to control). Additionally, monocytes stimulated with C. albicans also released interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8). However, alpha-mannan or beta-glucan failed to inhibit IL-1 beta release. These data indicate that C. albicans induces monocytes to release AA and inflammatory cytokines. Furthermore, AA, but not cytokine liberation, is partially mediated by alpha-mannan and beta-glucan components of the fungus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.