ArticleIn vitro cellular & developmental biology. Animal1996
Establishment and characterization of a bovine mammary epithelial cell line with unique properties.
Article in In vitro cellular & developmental biology. Animal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 125 citations in OpenAlex.
- From inserts to 3D spheroids: MAC-T and BME-UV1 co-culture models for in vitro reconstruction of the bovine mammary epithelial architecture.Veterinary research · 2026Article
- Chemerin Stimulates the Secretory Activity of BME-UV1 Bovine Mammary Epithelial Cells.International journal of molecular sciences · 2024Article
- Adipocyte-Derived Paracrine Factors Regulate the In Vitro Development of Bovine Mammary Epithelial Cells.International journal of molecular sciences · 2023Article
- Successful editing and maintenance of lactogenic gene expression in primary bovine mammary epithelial cells.In vitro cellular & developmental biology. Animal · 2023Article
- Candidate genes for mastitis resistance in dairy cattle: a data integration approach.Journal of animal science and biotechnology · 2023Article
- Assessing extracellular vesicles from bovine mammary gland epithelial cells cultured in FBS-free medium.Extracellular vesicles and circulating nucleic acids · 2021Article
- Antimicrobial Effects of Conditioned Medium From Amniotic Progenitor CellsFrontiers in veterinary science · 2019Article
- Article
- Development and validation of immortalized bovine mammary epithelial cell line as an in vitro model for the study of mammary gland functions.Cytotechnology · 2018Article
- 3-Bromopyruvate as an Alternative Option for the Treatment of Protothecosis.Frontiers in pharmacology · 2018Article
- Establishment of immortalized mouse intestinal epithelial cells line and study of effects of Arg-Arg on inflammatory response.In vitro cellular & developmental biology. Animal · 2017Article
- Mammary alveolar cell asAsian-Australasian journal of animal sciences · 2017Article
- Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland.PloS one · 2017Article
- Staphylococcus aureus Phenol-Soluble Modulins Impair Interleukin Expression in Bovine Mammary Epithelial Cells.Infection and immunity · 2016Article
- Can widely used cell type markers predict the suitability of immortalized or primary mammary epithelial cell models?Biological research · 2016Article
- Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells.Cell death discovery · 2016Article
- ABC- and SLC-Transporters in Murine and Bovine Mammary Epithelium--Effects of Prochloraz.PloS one · 2016Article
- Correlation of hypothetical virulence traits of two Streptococcus uberis strains with the clinical manifestation of bovine mastitis.Veterinary research · 2015Article
- Lineage-specific markers of goat mammary cells in primary culture.In vitro cellular & developmental biology. Animal · 2014Article
- Bovine mammary epithelial cell cultures for the study of mammary gland functions.In vitro cellular & developmental biology. Animal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clonal cell lines (BME-UV) were established from primary epithelial cells by stable transfection with a plasmid, carrying the sequence of the simian virus 40 early region mutant tsA58, encoding the thermolabile large T antigen. The BME-UV cells have undergone more than 300 population doublings and produce intranuclear large T antigen. At low confluency, growing islands of cells are apparent exhibiting the characteristic cobblestone morphology of epithelial cells. The BME-UV cells expressed functional markers such as microvilli and desmosomes and biochemical markers of mammary epithelial cells such as a repertoire of cytokeratins. The BME-UV cells are capable of synthesizing low levels of alpha-lactalbumin and alpha s1-casein (50 ng/ml of medium/24 h). One of the cell lines, BME-UV1 showed enhanced proliferation in the presence of epidermal growth factor (EGF) and insulinlike growth factor I (IGF-I). The BME-UV1 cell line is the only known bovine mammary epithelial cell line responsive to EGF. The BME-UV cells grown on collagen at low confluency are capable of developing very long projections that most likely allow for communication between cells at a distance from each other. The BME-UV cells may become a valid model system to examine bovine mammary epithelial proliferation and differentiation and cell-to-cell communication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.