ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Emergence of activity-dependent, bidirectional control of microtubule-associated protein MAP2 phosphorylation during postnatal development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 90 citations in OpenAlex.
- Differential regulation of MAP2 by phosphorylation events in proline-rich versus C-terminal domains.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- More than a marker: potential pathogenic functions of MAP2.Frontiers in molecular neuroscience · 2022Article
- MAP2 is differentially phosphorylated in schizophrenia, altering its function.Molecular psychiatry · 2021Article
- Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth.eLife · 2019Article
- MAP2 immunoreactivity deficit is conserved across the cerebral cortex within individuals with schizophrenia.NPJ schizophrenia · 2019Article
- Mesoscale Architecture Shapes Initiation and Richness of Spontaneous Network Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The neuritogenic and neuroprotective potential of senegenin against Aβ-induced neurotoxicity in PC 12 cells.BMC complementary and alternative medicine · 2016Article
- A novel function of the cell polarity-regulating kinase PAR-1/MARK in dendritic spines.Bioarchitecture · 2011Article
- Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization.The Journal of comparative neurology · 2008Article
- Intrinsic disorder in scaffold proteins: getting more from less.Progress in biophysics and molecular biology · 2008Review
- Very-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2.The Journal of cell biology · 2007Article
- Neuronal cotransport of glycine receptor and the scaffold protein gephyrin.The Journal of cell biology · 2006Article
- Brain-derived neurotrophic factor mediates activity-dependent dendritic growth in nonpyramidal neocortical interneurons in developing organotypic cultures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Making sense of the multiple MAP-2 transcripts and their role in the neuron.Molecular neurobiology · 1998Review
- Role of MAP kinase in neurons.Molecular neurobiology · 1998Review
- Experience-dependent modifications in MAP2 phosphorylation in rat olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Microtubule-associated proteins (MAPs) in the peripheral nervous system during development and regeneration.Journal of molecular neuroscience : MN · 1997Review
- The effects of the dynamic state of the cytoskeleton on neuronal plasticity.Neuroscience and behavioral physiologyArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Pronounced changes in neuronal morphology occur as synapses mature; however, little is known about how synaptic transmission regulates the developing neuronal cytoskeleton. The postsynaptic, microtubule-associated protein MAP2 is a target of multiple, calcium-dependent signaling pathways activated by synaptic transmission. Here we demonstrate that MAP2 phosphorylation is differentially regulated across development. In 32P-labeled hippocampal slices prepared from adult rats, depolarization stimulated a bidirectional change in the phosphorylation of immunoprecipitated MAP2. A transient increase was mediated by metabotropic glutamate receptors (mGluRs) and stimulation of mitogen-activated protein kinases (MAPKs), Ca2+/calmodulin-dependent protein kinases (CaMKs), and protein kinase C (PKC). This increase was followed by a persistent dephosphorylation mediated by NMDA receptors and activation of protein phosphatase 2B (PP2B or calcineurin). In contrast, depolarization of neonatal hippocampal slices stimulated exclusively a net increase in MAP2 phosphorylation, which was attenuated by inhibitors of MAPKs, but not CaMKs or PKC. Furthermore, although incubation in NMDA induced a time-dependent decrease in MAP2 phosphorylation in both adults and neonates, this effect was both less robust and less sensitive to calcineurin inhibitors in neonates than in adults. These data indicate that the mechanisms coupling glutamate release to MAP2 dephosphorylation are relatively lacking in the neonatal hippocampus. Highly phosphorylated MAP2 is impaired in its ability to stabilize microtubules and actin filament bundles in vitro. The neonatal propensity toward glutamate-stimulated MAP2 phosphorylation may serve to reduce cytoskeletal stability and permit dendritic arborization early in postnatal development. In mature neurons, the bidirectional control of MAP2 phosphorylation may participate in activity-dependent synaptic remodeling.
Indexed as
Identifiers
8922419PMC6579079W1565722988What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.