ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Two alternatively spliced forms of the cGMP-gated channel alpha-subunit from cone photoreceptor are expressed in the chick pineal organ.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- Alternative splicing governs cone cyclic nucleotide-gated (CNG) channel sensitivity to regulation by phosphoinositides.The Journal of biological chemistry · 2014Trial
- Retinal Cyclic Nucleotide-Gated Channel Regulation by Calmodulin.International journal of molecular sciences · 2022Review
- Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides.The Journal of general physiology · 2013Article
- ROS-GC subfamily membrane guanylate cyclase-linked transduction systems: taste, pineal gland and hippocampus.Molecular and cellular biochemistry · 2010Review
- Native cone photoreceptor cyclic nucleotide-gated channel is a heterotetrameric complex comprising both CNGA3 and CNGB3: a study using the cone-dominant retina of Nrl-/- mice.Journal of neurochemistry · 2008Article
- Somatostatin peptides produce multiple effects on gating properties of native cone photoreceptor cGMP-gated channels that depend on circadian phase and previous illumination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Expression of the G protein gammaT1 subunit during zebrafish development.Gene expression patterns : GEP · 2007Article
- Calcium-sensitive ROS-GC1 signaling outside of photoreceptors: a common theme.Molecular and cellular biochemistry · 2002Review
- Cyclic nucleotide-gated channels: shedding light on the opening of a channel pore.Nature reviews. Neuroscience · 2001Review
- Ligand sensitivity of the 2 subunit from the bovine cone cGMP-gated channel is modulated by protein kinase C but not by calmodulin.The Journal of physiology · 2001Article
- A cGMP-signaling pathway in a subset of olfactory sensory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Cloning and immunocytochemical localization of a cyclic nucleotide-gated channel alpha-subunit to all cone photoreceptors in the mouse retina.The Journal of comparative neurology · 2000Article
- Mutating three residues in the bovine rod cyclic nucleotide-activated channel can switch a nucleotide from inactive to active.Biophysical journal · 2000Article
- Molecular determinants of the modulation of cyclic nucleotide-activated channels by calmodulin.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Molecular determinants of a Ca2+-binding site in the pore of cyclic nucleotide-gated channels: S5/S6 segments control affinity of intrapore glutamates.The EMBO journal · 1999Article
- Ca2+ permeation in cyclic nucleotide-gated channels.The EMBO journal · 1999Article
- Cyclic nucleotide-gated channels on the flagellum control Ca2+ entry into sperm.The Journal of cell biology · 1998Article
- Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human.Biophysical journal · 1998Article
- Three amino acids in the C-linker are major determinants of gating in cyclic nucleotide-gated channels.The EMBO journal · 1998Article
- Developmental expression pattern of phototransduction components in mammalian pineal implies a light-sensing function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light sensitivity of the pineal has been retained in most vertebrates, except mammals. Retinal photoreceptors and pinealocytes share common components of light-dependent signaling pathways. In particular, an ion channel gated by cGMP has been electrophysiologically identified in chick pinealocytes; however, the physiological function of a light-sensitive enzyme cascade is not known, and primary structures of only a few pineal components have been determined. By PCR analysis and cloning of the respective cDNA, we show that the chick pineal expresses the alpha-subunit of the cyclic nucleotide-gated (CNG) channel of rod photoreceptors and two short forms of the cone CNG channel. Analysis of the chick cone CNG channel gene reveals that these forms are produced by alternative splicing, which removes either one or two exons from the transcript. The shorter splice variant is functional when heterologously expressed, and it is approximately twofold more sensitive to activation by cGMP than the cone CNG channel. The chick cone CNG channel and the pineal splice form are both modulated by Ca2+/calmodulin (CaM). The CaM sensitivity might be mediated by a putative CaM-binding site in an N-terminal segment encoded by exon 4. This exon is missing in the gene for the rod CNG channel alpha-subunit. Pineal CNG channels are candidates for receptor-mediated Ca2+ entry into pinealocytes and may be an important element of signaling pathways that control the light response and secretion of the pineal hormone melatonin.
Indexed as
Identifiers
8922401PMC6579096W1658856691What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.