ArticleThe Journal of cell biology1996
Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 124 citations in OpenAlex.
- The Proapoptotic GeneCells · 2021Article
- ProapoptoticInternational journal of molecular sciences · 2021Article
- Review
- DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies.Molecular neurobiology · 2017Review
- Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells.Journal of neurochemistry · 2016Article
- Identification of two novel functional p53 responsive elements in the herpes simplex virus-1 genome.Virology · 2014Article
- DAPK1-p53 interaction converges necrotic and apoptotic pathways of ischemic neuronal death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Apoptotic cell death in neuroblastoma.Cells · 2013Article
- UBE4B: a promising regulatory molecule in neuronal death and survival.International journal of molecular sciences · 2012Review
- Bmi1 is down-regulated in the aging brain and displays antioxidant and protective activities in neurons.PloS one · 2012Article
- Interaction of Pax6 with SPARC and p53 in brain of mice indicates Smad3 dependent auto-regulation.Journal of molecular neuroscience : MN · 2010Article
- Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2009Article
- p63 antagonizes p53 to promote the survival of embryonic neural precursor cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways.The EMBO journal · 2006Article
- Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors.Molecular neurobiology · 2006Review
- Involvement of p53 and Fas/CD95 in murine neural progenitor cell response to ionizing irradiation.Oncogene · 2004Article
- p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Programmed cell death is an ongoing process in both the developing and the mature nervous system. The tumor suppressor gene, p53, can induce apoptosis in a number of different cell types. Recently, the enhanced expression of p53 has been observed during acute neurological disease. To determine whether p53 overexpression could influence neuronal survival, we used a recombinant adenovirus vector carrying wild type p53 to transduce postmitotic neurons. A control consisting of the same adenovirus vector background but carrying the lacZ reporter expression cassette was used to establish working parameters for the effective genetic manipulation of sympathetic neurons. We have found that recombinant adenovirus can be used at titers sufficiently high (10 to 50 multiplicity of infection) to transduce the majority of the neuronal population without perturbing survival, electrophysiological function, or cytoarchitecture. Moreover, we demonstrate that overexpression of wild type p53 is sufficient to induce programmed cell death in neurons. The observation that p53 is capable of inducing apoptosis in postmitotic neurons has major implications for the mechanisms of cell death in the traumatized mature nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.