ArticleThe Journal of cell biology1996
Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 98 citations in OpenAlex.
- Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain.Nature neuroscience · 2024Article
- Tankyrase Regulates Neurite Outgrowth through Poly(ADP-ribosyl)ation-Dependent Activation of β-Catenin Signaling.International journal of molecular sciences · 2022Article
- A Perspective on the Role of Dynamic Alternative RNA Splicing in the Development, Specification, and Function of Axon Initial Segment.Frontiers in molecular neuroscience · 2019Article
- A dominant dendrite phenotype caused by the disease-associated G253D mutation in doublecortin (DCX) is not due to its endocytosis defect.The Journal of biological chemistry · 2018Article
- Xenopus laevis neuronal cell adhesion molecule (nrcam): plasticity of a CAM in the developing nervous system.Development genes and evolution · 2017Article
- Long-term maintenance of Na+ channels at nodes of Ranvier depends on glial contact mediated by gliomedin and NrCAM.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Time dependent integration of matrix metalloproteinases and their targeted substrates directs axonal sprouting and synaptogenesis following central nervous system injury.Neural regeneration research · 2014Article
- Genetic aspects of autism spectrum disorders: insights from animal models.Frontiers in cellular neuroscience · 2014Review
- Neuro-glial interactions at the nodes of Ranvier: implication in health and diseases.Frontiers in cellular neuroscience · 2013Review
- Regulation of adhesion by flexible ectodomains of IgCAMs.Neurochemical research · 2013Review
- Distinct cis regulatory elements govern the expression of TAG1 in embryonic sensory ganglia and spinal cord.PloS one · 2013Article
- Doublecortin (DCX) mediates endocytosis of neurofascin independently of microtubule binding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Proteomic analysis of the presynaptic active zone.Experimental brain research · 2012Review
- Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier.The Journal of biological chemistry · 2011Article
- The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment.The Journal of biological chemistry · 2011Article
- NrCAM deletion causes topographic mistargeting of thalamocortical axons to the visual cortex and disrupts visual acuity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Insulin-like 3 exposure of the fetal rat gubernaculum modulates expression of genes involved in neural pathways.Biology of reproduction · 2010Article
- Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin.The Journal of biological chemistry · 2009Article
- The promotive effects of thymosin beta4 on neuronal survival and neurite outgrowth by upregulating L1 expression.Neurochemical research · 2008Article
- Glial and neuronal isoforms of Neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system.The Journal of cell biology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurofascin and NrCAM are two axon-associated transmembrane glycoproteins belonging to the L1 subgroup of the Ig superfamily. In this study, we have analyzed the interaction of both proteins using neurite outgrowth and binding assays. A neurofascin-Fc chimera was found to stimulate the outgrowth of tectal cells when immobilized on an inert surface but not as a soluble form using polylysine as substrate. Antibody blocking experiments demonstrate that neurite extension on immobilized neurofascin is mediated by NrCAM on the axonal surface. Under the reverse experimental conditions where NrCAM induces neurite extension, F11, and not neurofascin, serves as axonal receptor. Binding studies using transfected COS7 cells and immunoprecipitations reveal a direct interaction between neurofascin and NrCAM. This binding activity was mapped to the Ig domains within neurofascin. The neurofascin-NrCAM binding can be modulated by alternative splicing of specific stretches within neurofascin. These studies indicate that heterophilic interactions between Ig-like proteins implicated in axonal extension underlie a regulation by the neuron.
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