ArticleThe Journal of cell biology1996
Midzone microtubule bundles are continuously required for cytokinesis in cultured epithelial cells.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 91 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 214 citations in OpenAlex.
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- A cortical pool of LIN-5 (NuMA) controls cytokinetic furrow formation and cytokinesis completion.The Journal of cell biology · 2025Article
- Lateral and longitudinal compaction of PRC1 overlap zones drives stabilization of interzonal microtubules.Molecular biology of the cell · 2023Article
- The fate of extra centrosomes in newly formed tetraploid cells: should I stay, or should I go?Frontiers in cell and developmental biology · 2023Review
- Hubbing the Cancer Cell.Cancers · 2022Review
- Functional midbody assembly in the absence of a central spindle.The Journal of cell biology · 2022Article
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- A Structural View on ESCRT-Mediated Abscission.Frontiers in cell and developmental biology · 2020Review
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- Choice between 1- and 2-furrow cytokinesis inMolecular biology of the cell · 2019Article
- Actomyosin contractility regulators stabilize the cytoplasmic bridge between the two primordial germ cells duringMolecular biology of the cell · 2017Article
- LET-99 functions in the astral furrowing pathway, where it is required for myosin enrichment in the contractile ring.Molecular biology of the cell · 2017Article
- Functional analysis of KIF20A, a potential immunotherapeutic target for glioma.Journal of neuro-oncology · 2017Article
- The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4.Molecular biology of the cell · 2016Article
- An astral simulacrum of the central spindle accounts for normal, spindle-less, and anucleate cytokinesis in echinoderm embryos.Molecular biology of the cell · 2014Article
- Binding of the CYK-4 subunit of the centralspindlin complex induces a large scale conformational change in the kinesin subunit.The Journal of biological chemistry · 2013Article
- Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis.The Journal of cell biology · 2013Article
- MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis.Journal of cell science · 2013Article
- RhoGEF and positioning of rappaport-like furrows in the early Drosophila embryo.Current biology : CB · 2012Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The current model of cytokinesis proposes that spindle poles and associated microtubules determine the cleavage plane, and, once the signal has been delivered to the cortex, the entire mitotic apparatus can be removed without affecting cell division. While supported by compelling data from Echinoderm embryos, recent observations suggest that the model may not be universally applicable. In this study, we have examined the relationship(s) among microtubules, chromosomes, and cleavage activity in living normal rat kidney (NRK) cells with multipolar mitotic figures. We found that cleavage activity correlated with the distribution of midzone microtubule bundles and Telophase Disc 60 protein (TD60) rather than the position of spindle poles. In addition, reduction of midzone microtubules near the cortex, by either nocodazole treatment or spontaneous reorganization in tripolar cells, caused inhibition or regression of furrowing. These results demonstrate that continuous interaction between midzone microtubule bundles and the cortex is required for successful cleavage in tissue culture cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.